Autophagy 2 Flashcards
1
Q
What does a mutation in autophagy genes mainly cause ?
A
Aggregates
2
Q
What causes Huntington’s?
A
polyglutamine expansion / too many Q repeats
3
Q
What aggragates in Parkinson’s?
A
alpha synuclein
4
Q
How can it be repaired
A
Chaperone mediated autop: LAMP2 recog cargo to transport in lysosome
5
Q
How can repair mech be prevented
A
Mutated versions of LAMP2 = A53T that blocks binding of prot
6
Q
Mitochondrial disfunction hypo ? Proof
A
could be cause of Parkinson’s cause damaged mito accumulate in P
Parkin et PINK 1 reg mitophagy and mut causes a certain % of P
