Autonomics: Sympatholytics

Question 1

Clonidine, guanfacine

Answer 1

Sympatholytics (α2-agonists)

clinical use: Hypertensive urgency (limited situations),
ADHD, Tourette syndrome, symptom control
in opioid withdrawal

Adverse effects: CNS depression, bradycardia, hypotension,
respiratory depression, miosis, rebound
hypertension with abrupt cessation

Question 2

α-methyldopa

Answer 2

Sympatholytics (α2-agonists)

Clinical use: Hypertension in pregnancy

Adverse effects: Direct Coombs ⊕ hemolysis, drug-induced
lupus

Question 3

tizanidine

Answer 3

Sympatholytics (α2-agonists)

Clinical use: Relief of spasticity

Adverse effects: Hypotension, weakness, xerostomia