Autonomics

Question 1

postganglionic parasympathetic neurotransmitter is typically ______ that binds _______ receptors

Answer 1

Acetylcholine

Muscarinic

Question 2

choline transport into the neuron body can be inhibited by

Answer 2

hemicholinium

Question 3

the major NT of the parasympathetic system

Answer 3

acetylcholine

Question 4

Release of NT at cholinergic synapse is mediated by

Answer 4

Ca2+ causing VAMPS and SNAPs to bind and vesicular release

Question 5

acetylcholine is stored in vesicles by what enzyme in the neuron what what can inhibit this process

Answer 5

VAT

can be inhibited by VEsamicol

Question 6

most postganglionic sympathetic neurons utilize the NT

Answer 6

norepinephrine

Question 7

metyrosine action

Answer 7

inhibits conversion of tyrosine to dopa

Question 8

reserpine aciton

Answer 8

inhibits high affinty antiporter for catecholamines located in wall of storage vesicle called VMAT (Vesicular monoamine transporter)

Question 9

action of cocaine/tricycline antidepressants

Answer 9

inhibits NET (norepinephrine transporter) which carries norepinephrine and similar molecules back into cell cytoplasm 
results in increase of transmitter activity because NET is partially responsible for termination of synaptic activity

Question 10

signal termination by metabolism of adrenergic NT is mediated by what two enzymes

Answer 10

COMT (catechol-O-methyltransferase) and MAO (monoamine oxidase)

Question 11

sympathetic innervation of bronchioles results in

Answer 11

dilation of bronchioles

Question 12

parasympathetic innervation of the bronchioles results in

Answer 12

constriction of the bronchioles

Question 13

M1, M3, M5 all induce the secondary signal

Answer 13

IP3/DAG –> Ca2+ increase

Question 14

M2 and M4 all induce what secondary signal

Answer 14

open K channels and inhibit AC (less cAMP)

Question 15

M1 is found in

Answer 15

CNS, sympathetic postganglionic neurons

Question 16

M2 is found

Answer 16

in the myocardium, smooth muscle, and CNS

handles parasympathetics

Question 17

M3 is found

Answer 17

endothelium - parasympathetic primarily
bronchiole smooth muscle - contraction 
GI smooth muscle - contraction 
GI sphincters - relaxes 
GI secretion - increases 
GU bladder wall - contracts 
GU sphincter - relaxes