Autonomics Flashcards

1
Q

Peripheral Nervous System breaks down into 2 sections

A

Afferent (towards brain and CNS) and Efferent (away from CNS towards periphery)

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2
Q

Efferent PNS breaks down into two sections

A

Somatic (to skeletal muscle) and Autonomic (goes to smooth muscle)

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3
Q

Autonomic, Efferent PNS breaks down into two sections

A

Sympathetic and Parasympathetic

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4
Q

Skeletal Muscle is Voluntary or Involuntary

A

Voluntary

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5
Q

Smooth muscle is Voluntary or Involuntary

A

Involuntary

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6
Q

parasympathetic

A

cranial sacral

  • long presynaptic fibers
  • nicotine receptors
  • Acetyl Choline
  • Myocartonic Receptors
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7
Q

Sympathetic

A

Thoracic Lumbar

  • short presynaptic fiber
  • nicotinic receptors
  • Norepinephrine
  • Alpha or beta receptors
  • 3 levels of synapse
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8
Q

Three ways the sympathetic chain can go

A
  1. Synapse at the same level as paravertebral ganglia
  2. down level, then synapse at the lower level
  3. level up, synapse at upper level, or bypass and synapse at prevertebral ganglion
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9
Q

6 general functions of the autonomic nervous system

A
  1. to preserve homeostasis, provoke rxns to to protect the individual
  2. Afferent impulses from the viscera elicit reflex responses (generally cannot be controlled voluntarily)
  3. Many fibers of the ANS are active maintaining a basal tone in most organs (ex: constriction of blood vessels)
  4. sympathetic and parasympathetic nervous systems are generally antagonistic with exceptions (salivary glands)
  5. Activation of sympathetic system is generally associated with defense mechanism (expenditure of energy, glycogenolysis, inc muscle tone)
  6. Activation of parasympathetic system is associated with conservative/restorative - decrease in BP and body temp.
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10
Q

All preganglionic fibers release

A

Acetyl Choline

neurotransmitter

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11
Q

What kind of receptor is found in all ganglia

A

Nicotinic

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12
Q

Norepinephrine to alpha beta receptors

A

Sympathetic

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13
Q

acetylcholine to muscarinic receptors

A

parasympathetic

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14
Q

Adrenergic Nerve - synthesis

A

Tyrosine
Dopa
Dopamine

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15
Q

Membrane depolarizes action potentials concerning what?

in adrenergic nerve

A

Ca2+

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16
Q

what is the receptor for neuronal uptake?

A

alpha II, found on post genetic fiber. It helps to uptake norepinephrine

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17
Q

Adrenoreceptor alpha 1 - target tissue

A

Vascular smooth muscle, skin, renal, and splanchnic. Gastrointestinal tract, sphincters. Bladder, sphincters. Radial muscle, iris.

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18
Q

Adrenoreceptor Alpha 1 - Mechanism of action

A

IP3, increase intracellular [Ca2+]

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19
Q

Adrenoreceptor alpha 2 - target receptor

A

Gastrointestinal tract, wall.

Presynaptic adrenergic neurons

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20
Q

Adrenoreceptor alpha 2 - mechanism in action

A

Inhibition of adenylyl cyclase, decreased cAMP

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21
Q

Adrenoreceptor beta 1 - target tissue

A

Heart
Salivary glands
Adipose tissue
Kidney

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22
Q

Adrenoreceptor beta 1 - mechanism in action

A

Stimulation of adenylyl cyclase, increased camp

23
Q

Adrenoreceptor beta 2 - target tissue

A

Vascular smooth muscle or skeletal muscle
Gastrointestinal tract, wall
Bladder, wall
Bronchioles

24
Q

Adrenoreceptor beta 2 - mechanism of action

A

Stimulation of adenylyl cyclase, increased camp

25
Q

Cholinoreceptors - Nicotinic - target tissue

A

Skeletal muscle, motor end plate
Postganglionic neurons, SNS and PNS
Adrenal Medulla

26
Q

Cholinoreceptors - Nicotinic - mechanism of action

A

Opening Na and K channels - depolarization

27
Q

Cholinoreceptors - Muscarinic - target tissue

A

All effector organs, PNS

Sweat glands, SNS

28
Q

Cholinoreceptors - Muscarinic - mechanism of action

A

IP3, increased intracellular [CA2+]

29
Q

Adrenoreceptors- alpha 1 agonists

A

Norepinephrine, phenylephrine

30
Q

Adrenoreceptors- alpha 1 antagonists

A

Phenoxybenzamine

Prazosin

31
Q

Adrenoreceptors- alpha 2 agonists

A

Clonidine

32
Q

Adrenoreceptors- alpha 2 antagonists

A

Yohimbine

33
Q

Adrenoreceptors- beta 1 agonists

A

Norepinephrine

Isoproterenol

34
Q

Adrenoreceptors- beta 1 antagonists

A

Propranolol
Metoprolol
(beta blockers for heart disease)

35
Q

Adrenoreceptors- beta 2 agonists

A

Epinephrine
Isoproterenol
Albuterol

36
Q

Adrenoreceptors- beta 2 antagonists

A

Propranolol

Butoxamine

37
Q

Cholinoreceptors - nicotinic - agonists

A

ACh
Nicotine
Carbachol

38
Q

Cholinoreceptors - nicotinic - antagonists

A

Curare

Hexamethonium (blocks ganglionic receptor but not neuromuscular junction)

39
Q

Cholinoreceptors - muscarinic - agonists

A

ACh
Muscarine
Carbachol

40
Q

Cholinoreceptors - muscarinic - antagonists

A

Atropine

41
Q

some drugs mimic norepinephrine for sympathetic and parasympathetic at what level

A

level of the receptor

42
Q

Hypothalamus

A

regulates breathing
temperature regulation, thirst. food intake
Sits atop the midbrain

43
Q

Heart - sympathetic - action and receptor

A

heart rate is up, receptor is Beta 1

44
Q

Heart - parasympathetic - action and receptor

A

Heart rate is down, receptor is M

45
Q

Bronchioles - sympathetic - action and receptor

A

action - dilates

receptor - Beta 2

46
Q

Bronchioles - parasympathetic - action and receptor

A

action - constricts

receptor - M

47
Q

Bladder - sympathetic - action and receptor

A

action -
wall, detrusor muscle - relaxes, B2 receptor
sphincter - contracts, A1 receptor

48
Q

Bladder - parasympathetic - action and receptor

A

action:
wall, detrusor muscle - contracts, M receptor
sphincter - relaxes, M receptor

49
Q

Male genitalia - sympathetic - action and receptor

A

Ejaculation, receptor alpha

50
Q

Male genitalia - parasympathetic - action and receptor

A

Erection, receptor M

51
Q

Eye - sympathetic - action and receptor

A

Radial muscle, iris dilates pupil (mydriasis), receptor is A1
[Circular sphincter muscle, iris]
Ciliary muscle - dilates (far vision) receptor is beta

52
Q

eye - parasympathetic - action and receptor

A
constricts pupil (miosis), receptor M
Contracts (near vision), receptor M
53
Q

skin - sympathetic - action and receptor

A

sweat glands, thermoregulatory **increase, receptor: M
Sweat glands, stress - increase, receptor alpha
pilomotor muscle (goose bumps) - contracts, receptor alpha