Autonomic receptors Flashcards
Alpha 1
Gq
Increase vascular smooth muscle contraction
Increase pupillary dilator muscle contraction (Mydriasis)
Increase intestinal and bladder sphincter muscle contraction
Alpha 2
Gi Decrease sympathetic outflow (in CNS) Decrease insulin release Decrease lipolysis Decrease aqueous humor production Increase platelet aggregation
Beta 1
Gs Increase heart rate Increase contractility Increase renin release Increase lipolysis
Beta 2
Gs Vasodilation Bronchodilation Increase lipolysis Increase insulin release Increase aqueous humor production Decrease uterine tone Ciliary muscle relaxation
Beta 3
Gs
Increase Lipolysis
Increase thermogenesis in skeletal muscle
M1
Gq
CNS
Enteric nervous system
M2
Gi
Decrease heart rate
Decrease contractility of atria
M3
Gq
Increase exocrine gland secretions (lacrimal, sweat, salivary, gastric acid)
Increase gut peristalsis
Increase bladder contraction
Bronchoconstriction
Increase pupillary sphincter muscle contraction (Miosis)
Ciliary muscle contraction (accommodation)
D1
Gs
Relaxes renal vascular smooth muscle
D2
Gi
Modulates transmitter release (esp. in brain)
H1
Gq Increase nasal and bronchial mucus production Increase vascular permeability Contraction of bronchioles Pruritus Pain
H2
Gs
Increase gastric acid secretion
V1
Gq
Increase vascular smooth muscle contraction
V2
Gs
Increase H20 permeability and reabsorption in collecting tubules of kidney