autonomic receptor types with locations & results (lecture 2)

Question 1

for the receptor M1 list the typical locations and result of ligand binding

Answer 1

CNS neurons, symp postganglionic neurons and some presynaptic sites
effect- formation of IP3 and DAG increased intracellular Ca

Question 2

for the receptor M2 list the typical locations and result of ligand binding

Answer 2

myocardium, smooth muscle, some presynaptic sites, CNS neurons
effects- opening of K channels and inhibition of adenylyl cyclase

Question 3

for the receptor M3 list the typical locations and result of ligand binding

Answer 3

exocrine glands, vessels (smooth muscle and endothelium) and CNS neurons
effects- formation of IP3 and DAG increased intracellular Ca

Question 4

for the receptor M4 list the typical locations and result of ligand binding

Answer 4

CNS neurons, possibly vagal nerve endings

effects- opening of K channels and inhibition of adenylyl cyclase

Question 5

for the receptor M5 list the typical locations and result of ligand binding

Answer 5

vascular endothelium, especially cerebral vessels, CNS neurons
effects- formation of IP3 and DAG increased intracellular Ca

Question 6

for the receptor N(n) list the typical locations and result of ligand binding

Answer 6

postganglionic neurons, some presynaptic cholinergic terminals
effects- opening of Na, K channels, depolarization

Question 7

for the receptor N(m) list the typical locations and result of ligand binding

Answer 7

skeletal muscle neuromuscular end plates

effects-opening of Na, K channels, depolarization

Question 8

for the receptor alpha1 list the typical locations and result of ligand binding

Answer 8

postsynaptic effector cells, especially smooth muscle

effects- formation of IP3 and DAG increased intracellular Ca

Question 9

for the receptor alpha2 list the typical locations and result of ligand binding

Answer 9

presynaptic adrenergic nerve terminals, platelets, lipocytes, smooth muscle
effects- inhibition of adenylyl cyclase, decrease cAMP

Question 10

for the receptor Beta1 list the typical locations and result of ligand binding

Answer 10

postsynaptic effector cells, esp heart, lipocytes, brain, presynaptic adrenergic and cholinergic nerve terminals, juxtaglomerular apparatus of renal tubules, ciliary body epithelium
effects- stimulation of adenylyl cyclase, increased cAMP

Question 11

for the receptor Beta2 list the typical locations and result of ligand binding

Answer 11

postsynaptic effector cells, especially smooth muscle and cardiac muscle
effects-stimulation of adenylyl cyclase and increased cAMP. activates cardiac Gi under some conditions

Question 12

for the receptor Beta3 list the typical locations and result of ligand binding

Answer 12

postsynaptic effector cells, especially lipocytes; heart

effects-stimulation of adenylyl cyclases and increased cAMP1

Question 13

for the receptor D1 (DA1), D5 list the typical locations and result of ligand binding

Answer 13

brain, effector tissues, especially smooth muscle of renal vascular bed
effects- stimulation of adenylyl cyclase and increased cAMP

Question 14

for the receptor D2 (DA2) list the typical locations and result of ligand binding

Answer 14

brain; effector tissues, especially smooth muscle of renal vascular bed
effects- inhibition of adenylyl cyclase; increased K conductance D3

Question 15

for the receptor D3 list the typical locations and result of ligand binding

Answer 15

brain

effects- inhibition of adenylyl cyclase D4

Question 16

for the receptor D4 list the typical locations and result of ligand binding

Answer 16

brain, cardiovascular system

effects- inhibition of adenylyl cyclase