Autonomic Nervous System drugs Flashcards
Sympathetic NS
Terminal Neurotransmitter: Norepinephrine
Parasympathetic NS
Terminal Neurotransmitter: Acetylcholine
Drugs that produces a response
Agonist
Drugs that blocks a response
Antagonist
Sympathetic=ADRENERGIC AGONIST:
ADRENERGIC ANTAGONIST:
**Parasympathetic=CHOLINERGIC** AGONIST:
CHOLINERGIC ANTAGONIST:
-STIMULATE THE SNS SYMPATHOMIMETIC
-INHIBIT THE SNS SYMPATHOLYTIC
-STIMULATE THE PNS PARA-SYMPATHOMIMETIC
-INHIBIT THE PNS PARA-SYMPATHOLYTIC
SYMPATHOMIMETICS/ ADRENERGIC AGONISTS
Stimulate adrenergic receptors
Nasal decongestant A1, B2
Pseudoephedrine; phenylephrine
Cardiac arrest; asthma A1, A2, B1,B2
THERAPEUTIC CLASS: Vasopressor
PHARMACOLOGIC CLASS: Adrenergic
Epinephrine
ADRENERGIC BLOCKERS/ADRENERGIC ANTAGONISTS
Decrease heart rate and Decreases blood pressure
Phentolamine, Phenoxybenzamine A1, A2 Hypertension
Prazosin, Terazosin A1 Hypertension
Pindolol B1, B2 Decrease CO, HR for patients with heart block
THERAPEUTIC CLASS: Anti-hypertensive
PHARMACOLOGIC CLASS: Alpha Blocker
PRAZOSIN
Mimic the parasympathetic neurotransmitter acetylcholine
CHOLINERGIC AGONISTS
Direct Acting
Bethanechol Increase muscle tone in bladder ang GIT
THERAPEUTIC CLASS: Urinary Stimulants
PHARMACOLOGIC CLASS: Cholinergic Agonists
INDICATIONS: acute post-operative and postpartum
INDIRECT ACTING REVERSIBLE
Edrophonium Diagnosis of MG
Physostigmine Overdose of atropine
ANTI-MUSCARINIC AGENTS
Atropine Mydriasis, Psychoplegiaprior to an eye surgery or exam
THERAPEUTIC CLASS: Anti-arrhythmics
PHARMACOLOGIC CLASS: Anti-cholinergic belladonna alkaloids
INDICATIONS: Bradycardia, anti-cholinesterase poisoning
GANGLIONIC BLOCKERS
NICOTINE
Stimulate and block cholinergic function
Increase production of neurotransmitters
Not useful in clinical practice