Autonomic nervous system Flashcards
What is the study of drugs that influence the ANS which controls involuntary physiological functions like heart rate, digestion, and RR?
autonomic pharmacology
What does the ANS control that drugs target?
cardiovascular, resp, GI, other systemic disorders
What does the sympathetic nervous system do to the eyes?
contracts radial muscle to dilate the eye (mydriasis)
What does the parasympathetic nervous system do to the eyes?
contraction of the circular muscle to constrict the eye (miosis)
How are nore/epi terminated?
reuptake, inactivated by COMT or MAO-Is
Review: receptors
sympathetic - adrenergic
parasympathetic - muscarinic, nicotinic
What does muscarinic M1 act on?
CNS neurons; sympathetic postganglionic neurons
What does muscarinic M2 act on?
myocardium, smooth muscle, CNS neurons
What does muscarinic M3 act on?
exocrine gland, vessels, CNS neurons
What does muscarinic M4 act on?
CNS neurons (cholinergic)
What does muscarinic M5 act on?
vascular endothelium, CNS neurons (cholinergic)
What does alpha 1 work on?
vascular smooth muscle (cholinergic)
What does alpha 2 work on?
presynaptic adrenergic nerve terminals (cholinergic)
What does beta 1 work on?
heart (cholinergic)
What does beta 2 work on?
vascular smooth muscle and cardiac muscle (cholinergic)
What does beta 3 work on?
lipocytes and bladder (cholinergic)
What are cholinergic agonists?
parasympathetiomimetics –> mimic effects of PNS
What type of drug is bethanechol, pilocarpine?
cholinergic agonists
What are cholinergic antagonists/anticholinergic drugs?
parasympatholytics –> block effects of PNS
What type of drug is atropine, scopolamine?
cholinergic antagonists
What are adrenergic agonists?
sympathomimetics –> mimic effect of SNS
What type of drugs are epinephrine, norepinephrine, albuterol?
adrenergic agonists
What are adrenergic antagonists?
sympatholytics –> blocking effect of SNS
What type of drugs are beta blockers and alpha blockers?
adrenergic antagonists