autonomic nervous system Flashcards

1
Q

central autonomic nervous system

A

subconscious but conscious override

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2
Q

peripheral autonomic nervous system

A

sympathetic and parasympathetic

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3
Q

what is SNS’s job?

A

fight or flight

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4
Q

SNS origins

A

thoracolumbar (T1-L2/3) (except the cervical ganglia which supplies the head)

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5
Q

SNS ganglia location

A

next to the spinal chord

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6
Q

SNS NTs

A

preganglionic synapse - ACH
postganglionic synapse - noradrenaline (except sweat glands and deep blood vessels - ACH)

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7
Q

SNS response

A

dilated pupils
dry mouth
uncongested nose
adrenaline release
chronotropy inotropy (heart)
vasodilation
smooth muscle in bronchi relax
constipation -> reduce GI blood supply
urinary retention/ fluid retention
renal (vasoconstriction -> increase renin -> further vasoconstriction)
reduce excessive heat

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8
Q

SNS receptors

A

Alpha 1 + 2
- 1 = arteriole constriction
- 2 = venous constriction (and coronary artery)
Beta 1 + 2
- 1 = heart (increase heart, increase contractility)
- 2 = lungs, uterus, skeletal blood vessels, bladder, eye, gut ,smooth muscle relaxation
agonist and antagonist of each

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9
Q

SNS receptor-targeted drugs

A

alpha 2 agonist - yohimbine
- medicine in vet practice
Beta 2 agonist - salbutamol
- asthma inhaler
- also used in premature labour (stop uterine stimulation)
Beta 1 agonist - atenolol
- lowers blood pressure
- taccharrthymia
- secondary MI prevention

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10
Q

what is the role of the parasympathetic nervous system?

A

rest and digest

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11
Q

PNS origins

A

craniosacral outflow
- cranial - 3 (oculomotor), 7 (facial/ otic ganglia), 9 (glossopharyngeal), 10 (vagus) nerves
- sacral - S2,3,4

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12
Q

PNS ganglia

A

near site of action
- cervical -> cervical area
- thoracic -> heart and lungs
- coeliac -> gut and genitourinary

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13
Q

PNS NTs

A

ACH in pre and post ganglionic synapse

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14
Q

PNS response

A
  • pupillary constriction - improves near vision
  • nasal engorgement
  • excess salivation
  • increased gastric secretions and blood flow
  • slow heart rate
  • broncho constriction
  • micturition/ defecation/ ejaculation
  • lacrimation
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15
Q

PNS receptors

A

muscarinic receptor (muscular)
- most in CNS (M2/M3)
- M2 = heart
- M3 = salivary glands, gut, bladder, blood vessels, eye
nicotinic receptor
- NMJ
- N2 - mainly in autonomic ganglia; some in brain

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16
Q

PNS receptor-targeted drugs

A

muscarinic receptor antagonist (M2)
- atropine
- reduces effect of ACH on the heart
- increases heart rate
M1 agonist - Xanomeline
- potential treatment of Alzheimer’s and Sz
N1 antagonist - succinylcholine
- stimulation, depolarised, muscle spent ad then paralysed
N2 antagonist - vecuronium bromide
- non-depolarising muscle blocker

17
Q

autonomic dysfunction - CVS

A

Brady tachycardia; hypotension

18
Q

autonomic dysfunction - GI

A

GI disturbance, excess salivation

19
Q

autonomic dysfunction - vascular

A

flushing, excess sweating

20
Q

autonomic dysfunction - eyes

A

visual disturbances

20
Q

autonomic dysfunction - GU

A

urgency, incontinence

21
Q

autonomic dysfunction - adrenal

A

feeling of dread/ panic

21
Q

autonomic dysfunction - respiratory

A

wheeze

22
Q

autonomic dysfunction - sexual

A

erectile dysfunction

23
Q

functions of the brain stem

A

cranial nerve function
conduit function
integrative functions

24
Q

brain stem death

A

paralysis and unconsciousness
apnoea
loss of cranial nerve function
- coning

25
Q

enteric nervous system

A

manages how the body digests food

26
Q

testing for brain stem death

A

two people must be present - one does the procedure and the other watches; few hours later they swap roles
- thin plastic tube placed down throat to see if they gag
- disconnected from ventilator for a short period of time to see if they attempt to breathe on their own
- eye is stroked with paper or cotton to provoke a response
- pressure on the forehead