Autonomic Nervous System Flashcards
ANS is apart of which other nervous system?
Peripheral Nervous System
ANS regulates activity of ______ and ________, glands, lymphoid, and some adipose tissue
smooth and cardiac muscle
where is the first neuron in the ANS found?
CNS
Where is the second neuron of the ANS found?
PNS
the first neuron is also called the _____?
preganglionic neuron
the second neuron is also called the ____?
postganglionic neuron
the primary transmitter of all preganglionic neurons is
acetylcholine
transmitter in ALL PSNS postganglionic neurons is
acetylcholine
transmitter in most SNS postganglionic neurons is
norepinephrine
postganglionic neuron- peripheral or central
peripheral
what neurotransmitter do we have in sweat glands?
acetylcholine
what neurotransmitter do we have in adrenal medulla?
epinephrine
what neurotransmitter do we have in renal vasculature
dopamine
preganglionic neurons have a (short/long) path to the parasympathetic nervous system
long
parasympathetic nervous system has which type of receptor
muscarinic
preganglionic neurons release ______ to activate ______ receptors on postganglionic neurons
acetylcholine, nicotine
postganglionic neurons have a (long/short) path in the parasympathetic nervous system
short
postganglionic neurons release ______ to activate ______ receptors on the target organ
acetylcholine, muscarinic
preganglionic neurons have a (long/short) path to the sympathetic nervous system
short
describe the synapse involved between preganglionic neurons and the sympathetic nervous system
postganglionic neurons near spinal cord
describe the synapse involved between preganglionic neurons and the parasympathetic nervous system
postganglionic neurons at or near organ
describe the synapse between postganglionic neurons and the parasympathetic nervous system
synapse on the target organ
describe the synapse between postganglionic neurons and the sympathetic nervous system
synapse on the target organ
what neurotransmitter is released when we get sweaty palms
norepinephrine
postganglionic neurons involved with thermoregulation release ______
acetylcholine
adrenal glands release ______ into systemic circulation
epinephrine
kidneys are affected by what neurotransmitter?
dopamine
which neurotransmitter is mainly synthesized locally- not in the ANS
dopamine
most postganglionic sympathetic neurons release what neurotransmitter? (asked twice=important)
norepinephrine
drugs are mostly (pre/post)ganglionic?
postganglionic
parasympathetic or sympathetic: Cholinergic
parasympathetic
parasympathetic or sympathetic: Adrenergic
sympathetic
muscarine and nicotine are part of which nervous system?
parasympathetic
acetylcholine, norepinephrine, and epinephrine are exogenous or endogenous
endogenous
what two cholinergic compounds are exogenous
muscarine and nicotine
drugs that mimic neurotransmitters are referred to as
receptor agonists
drugs that block neurotransmitters are referred to as
receptor antagonists
what are the two primary ANS receptors?
cholinoceptors and adrenoceptors
cholinoreceptors consist of which two subreceptors?
muscarinic and nicotinic
adrenoreceptors consist of which two subreceptors?
alpha and beta
nicotine receptors are found where?
ganglionic, skeletal muscle, neuronal CNS
nicotinic receptor has how many subunits
5
nicotinic receptor:
open _____-gated __ channels depolarize the membrane, lead to opening of _____-gated __ channels to produce action potential
ligand, Na+, voltage, sodium
everything that is cholinergic deals with which neurotransmitter?
acetylcholine
all muscarinic receptors are _______
GCPRs
M1, M3, and M5 signal transduction goes through which g protein
Gq
M2 and M4 signal transduction goes through which g protein
Gi
Gq pathway goes through ___ and ___
IP3 and DAG
most common second messenger in regards to Gi and Gs
cAMP
main function of a1 receptor
mediate vasoconstriction
a1 mostly found where
smooth muscle
a1 signals via ___ pathway
Gq
a2 signals via __ pathway
Gi
a2 found (pre/post) synaptically and function as autoreceptors to inhibit _________ ________
pre, sympathetic output
B1, B2, B3 subtypes signal via ___ pathway
Gs
M and B receptors are (opposing/unopposing)
opposing
many drugs exhibit _________ effects
anticholinergic
ANS deals with which common health topics
Blood pressure, heart function, bronchoconstriction/dilation
pharmacology of sympathetic mechanisms involving ________ and ______ and their receptors = adrenergic pharmacology
norepinephrine and epinephrine
pharmacology of parasympathetic mechanisms involving _________ and its receptors= cholinergic pharmacology
acetylcholine
adrenergic response in the heart:
(increase/decrease) rate of contraction and force of contraction
increase, increase
cholinergic response in the heart:
(increase/decrease) rate of contraction and force of contraction
decrease, decrease
mainly which receptor for adrenergic response in the heart
B1
mainly which subunit for cholinergic response in the heart
M2
3 sites with predominant tone that is sympathetic
arterioles, veins, sweat glands
important target for bronchodilation (one of the subunits)
B2