Autonomic Drugs Flashcards
Muscarinic Agonist (M1, M2, M3) U: Bowel and bladder atony
Betanechol
Muscarinic and Nicotinic Agonist
U: Cataracts
Carbachol
Muscarinic Agonist (M3) U: Sjogren Syndrome, Sicca Syndrome
Pilocarpine
Nicotinic Agonist
U: Smoking cessation
Varenicline
Acetylcholinesterase Inhibitor
U: Tensilon Test
Edrophonium
Acetycholinesterase Inhibitor
DOC: Myasthenia Gravis
U: Reversal of Muscle Relaxants; Ogilvie Syndrome
Neostigmine
Acetylcholinesterase Inhibitor
U: Alzheimer’s Disease
Rivastigmine
Non-selective Muscarinic Antagonist
Hyoscine-N-Butyl-Bromide
Scopolamine
Non-selective Muscarinic Antagonist
DOC: Organophosphate Toxicity
SE: Hyperthermia
Atropine
Non-selective Muscarinic Antagonist
Shortest DOA
Tropicamide
Non-selective Muscarinic Antagonist
U: Bronchial Asthma
Ipratropium, Tiotropium
Non-selective Muscarinic Antagonist
U: Urinary incontinence and urgency
Oxybutinin
Chemical antagonist of Organophosphates
Given within 6-8 hours post-exposure
Pralidoxime
Sympatomimetic (A1, B1, B2)
DOC: Anaphylaxis
Epinephrine
Sympatomimetic (A1, B1, B2)
Effect: Alpha > Beta
Norepinephrine
Sympatomimetic (A1, B1, D1)
Dopamine
Non-selective Beta Agonist
U: Bronchial Asthma
Isoproterenol
A1 Agonist
U: Decongestant
SE: Rhinitis Medicamentosa
Phenylephrine
A2 Agonist
SE: Rebound Hypertension
Clonidine
A2 Agonist
U: Pre-ecclampsia
SE: Hemolytic Anemia
Methyldopa
A2 Agonist
U: Glaucoma
Apraclonidine
Brimonidine
B1 Agonist
U: Cardiogenic Shock
Dobutamine
B2 Agonist
DOC: Bronchial Asthma (Acute)
Salbutamol
D1 Agonist
U: Hypertension
Fenoldopam
D2 Agonist
U: Hyperprolactinemia, Parkinson’s Disease
Bromocriptine
Non-selective Alpha Antagonist
Irreversible
U: Pheochromocytoma
Phenoxybenzamine
Non-selective Alpha Antagonist
Reversible
U: Rebound HPN, Pheochromocytoma
Phentolamine
A1 Antagonist
U: Co-existing HPN and BPH
Prazosin
Doxazosin
Terazosin
A1a Antagonist
Prostate-selective
Tamsulosin
Non-selective Beta Antagonist
A1 Antagonist
U: Pheochromocytoma
Safe for pregnancy
Labetalol
Non-selective Beta Antagonist
A1 Antagonist
U: Pheochromocytoma
Reduces mortality in HF
Carvedilol
Non-selective Beta Antagonist
Longest half-life
Nadolol
Selective Beta Antagonist
Shortest half-life
U: SVT, Thyroid Storm
Esmolol
Beta Antagonists
Intrinsic Sympatomimetic Activity
Pindolol (Non-selective)
Acebutolol (Selective)
Beta Antagonists
No local anesthetic effects
Timolol (Non-selective)
Betaxolol (Selective)
Selective Beta Antagonist
Vasodilatory effect
Nebivolol
B2 Agonist
U: Tocolytic
Terbutaline
Non-selective Muscarinic Antagonist
U: Parkinson’s Disease
Benztropine
Biperiden
Trihexyphenidyl
