Autonomic Drugs Flashcards
(45 cards)
Treatment for neurogenic orthorstatic hypotension.
Pyridostigmine (AChE inhibitor)
Name the drugs that can cause bronchoconstriction as an AE. Name their mechanisms of action.
1 and 2. Carvedilol and labetalol: a1 and beta antagonists.
- Metropolol: B1 antagonist but can bind to B2 also.
- Propranolol: non-selective beta blocker.
Treats performance anxiety.
Propranolol (non-selective B blocker)
Extravasation necrosis SAE.
Norepinephrine
What is alpha-methyldopa converted to?
alpha-methylnorephrine
Treatment for shock.
Dopamine
Treats gestational hypertension.
a-methyldopa (a2 agonist)
Which drugs cause orthostatic hypotension as a SAE?
- Clonidine (centrally-acting a2 agonist)
- a-methyldopa (centrally-acting a2 agonist)
- Doxazosin (a1 antagonist)
Which drug is used for reversal of vagal bradycardia?
Atropine (non-selective muscarinic antagonist)
Which drugs cause “local necrosis” as a SAE?
Dopamine and epinephrine
What is an antidote for cholinesterase inhibitor toxicity?
Atropine (non-selective muscarinic antagonist)
Name the mechanism of action and corresponding physiologic response of drug binding:
Phenoxybenzamine
Irreversible a1 and a2 receptor antagonist
Vasodilation and increased epi and norepi release –> increased HR and contractility (B1) and skeletal muscle vasodilation (B2)
Name the mechanism of action:
Isoproterenol
Non-selective beta agonist
What does stimulation of B2 receptors do?
Dilation of skeletal muscle vasculature and dilation of bronchiolar smooth muscle
Name the mechanism of action:
Phentolamine
What other drug that we know has this same mechanism of action?
Non-selective alpha antagonist
Phenoxybenzamine is also a non-selective alpha antagonist
Name the mechanism of action:
a-methyldopa
What other drug that we know has this same mechanism of action?
a2 agonist
clonidine is also an a2 agonist
Name the mechanism of action and corresponding physiologic response of drug binding:
Darifenacin
M3 blocker
stops smooth muscle contraction in bladder and glands - used for overactive bladder
In what organ are dopaminergic receptors found and what happens when they bind dopamine?
Found in the kidneys; binding increases renal blood flow
Describe alpha and beta receptor affinity for norepinephrine.
a1 > a2 > B1 > B2
Describe alpha and beta receptor affinity for epinephrine (low doses).
B2 > B1 > a1 > a2
Name the mechanism of action:
Doxazosin
What other drug has the same mechanism of action?
a1 antagonist
prazosin as well (anything that ends with -osin is an a1 antagonist)
Name the mechanism of action:
Midodrine
a1 agonist
Name the mechanism of action:
Dobutamine
B1 agonist
Name the mechanism of action:
Phenylephrine
alpha agonist
