autonomic drugs

Question 1

anticholinergics MOA

Answer 1

block post-synaptic muscarinic receptors - stop parasympathetic nervous system - help bradycardia

Question 2

atropine

Answer 2

type of anticholinergic
used to treat bradycardia during anaesthesia (emergencies only)
dont use in horses

Question 3

glycopyrrolate

Answer 3

also used to treat bradycardia during anaesthesia
less profound increase in heart rate, slower onset -> not recommended for emergencies

Question 4

sympathomimetics

Answer 4

mimic the stimulation of the sympathetic nervous system

Question 5

dopamine

Answer 5

CRI
most common sympathomimetic in small animals
don’t use in horses
given when patient is hypotensive during anaesthesia - treats low contractility of the heart and direct vasodilation causes by anaesthetics

Question 6

dosages of dopamine

Answer 6

low dose = dopamine receptors, increased renal blood flow
moderate dose = B2 receptors, increased contractility and HR
high dose = A1+2 receptors, vasoconstriction

Question 7

adrenaline

Answer 7

emergency use only
positive inotrope, chronotrope, vasoconstrictor, bronchodilator
given during: anaphylactic shock, cardiac arrest, hypotension
(epipens)

Question 8

noradrenaline

Answer 8

positive inotrope, chronotrope, vasoconstrictor, bronchodilator
emergency use