Automation Flashcards
What is the 1st clot detection instrument that measures change in viscosity?
Koaguloviskosimeter
What is the manual reagent that accelerates clotting?
Calcium Chloride
What is the principle of Mechanical End Point Detection?
Measures change in conductivity between two metal electrodes in plasma.
Give two advantages of Mechanical End Point Detection.
- Not affected by icteric or lipemic plasma
* Sensitive end point
What is the principle of Photo-Optical End Point Detection?
Detects change in plasma optical density during clotting.
What instrument records the passage of a light specified wavelength through plasma?
Photodetector
When the optical density rises to a predetermined variance from baseline, the timer stops. What does it indicate?
Clot formation
What is the fixed wavelength used in Photo-Optical End Point Detection?
500-600 nm
It is a modified optical end point.
Nephelometric End Point Detection
What is the principle of Nephelometric End Point Detection?
Measures the 90 degree angle or forward angle light scatter.
Produces incident light
Light Emitting Diode
Detects variation in light scatter at 90 degree (side scatter) and 180 degree angle (forward)
Photodetector
It is an isolated specific chemical reaction rather than clot based
Chromogenic End Point Detection
Chromogenic End Point Detection is useful for?
- Patient with circulation inhibitors
* Patient who are on anticoagulant treatment
What is the end color of Para-nitroaniline?
Yellow
