Autoimmunity And Tolerance

Question 1

Define autoimmunity and its criteria

Answer 1

Adaptive immune response with specifics for self antigens. Always involves lymphocytes are generated via random recombination of gene segments and is possible to generate receptors agonist self. But there are factors that trigger the transition between autoimmunity to autoimmune disease eg genetic susceptibility and infection.

Loads of criteria

Loss environmental factors affecting self tolerance

Question 2

Describe the mechanism of autoimmunity

Answer 2

The breaking of T-cell tolerance because of self tissue always present and autoimmune are chronic conditions. Effector mechanisms resemble those of hypersensitivity (types 2-4)