Autoimmunity Flashcards
Define autoimmunity
Immune response against the host due to the loss of immunological tolerance of self-antigens
What is the self antigen for addisons disease?
Steroid-21 hydroxylase
What type of hypersensitivity reaction is lupus?
type 3
Define specificity
the % of individuals who do not have condition that test excludes
Define Sensitivity
the % of individuals with a condition that the test identifies
How long does IgG tranfer to neonates last?
6 months (then disease state ends)
Which race is lupus most common in?
afro-caribbean
What should you ask in a history for autoimmune rheumatic disease?
“gloves and sweater approach”, Raynauds, muscle weakness, hair loss, mouth ulcers, nose bleeds, pleuritic chest pain
How many criteria need to be met for definite lupus?
4 out of 11
Which type of drugs is used to treat RA and lupus?
DMARDs (disease modifying antirheumatic drugs)
