Autoimmunity Flashcards
1
Q
What is the role of AIRE protein?
A
Thymic deletion of autoreactive T-cells
2
Q
Why do autoimmune conditions go down in pregnancy?
A
Due to down regulation of interferon type i gamma because of increased progesterone release
3
Q
Which HLAs are strongly associated with coeliac disease?
A
DQ2 and 8
4
Q
Which auto antibody is upregulated in coeliac disease?
A
transglutaminase 2
5
Q
Should the following be used in: RA, SLE, or both? AntiTNF, anti-B cell, glucocorticoids, immunosuppressors?
A
Anti-TNF- RA not SLE
Anti-B cell- Both
Glucocorticoids- Both
Immunosuppressors- Both
