Autoimmune Liver Disease Flashcards
1
Q
How common is autoimmune liver disease in childhood?
A
1:10,000
2
Q
Who is autoimmune liver disease more common in?
A
Females
3
Q
Why is autoimmune liver disease more common in females?
A
Girls respond in a different way to infection, vaccination, and trauma, exhibiting increased antibody production and more T-helper 2-predominant immune response, whereas a Th1 response and inflammation are usually seen in males
4
Q
Is there a genetic component to autoimmune hepatitis?
A
Yes there is a genetic predisposition
5
Q
What genes are associated with the development of autoimmune hepatitis?
A
HLA B8/DR3
6
Q
How do genetics influence the risk of developing autoimmune hepatitis?
A
The genes a person inherits affect the number of cells in the adaptive immune system
