autoimmune hemolytic anemia

Question 1

what is compensated?

Answer 1

when rbc production nearly equal to the rate of rbc destruction

Question 2

hemolytic anemia is often demonstrated in a blood smear by what?

Answer 2

macrophages, spherocytes, and a reticulocyte count greater than 3%

Question 3

Autoimmune Hemolytic Anemia may be diagnosed and classified as what?

Answer 3

cold reactive, warm reactive, and drug induced

Question 4

at what temperature is benign cold autoantibodies encountered?

Answer 4

4 degrees celsius

Question 5

how are cold autoantibodies significant?

Answer 5

they are igM and can activate in vitro. occasionally they can cause immune hemolytic anemia

Question 6

what happens if an individuals RBCS are heavily coated with cold agglutinins?

Answer 6

they may agglutinate and cause false positives reactions

Question 7

what will the DAT of a patient with benign cold autoagglutinins read?

Answer 7

negative

Question 8

i adults may produce what?

Answer 8

alloanti-I

Question 9

Cold reactive immune hemolytic anemia may cause what?

Answer 9

mycoplasma pneumonia or infectious mononucleosis

Question 10

what is the antibody specificity with Cold hemagglutinin disease?

Answer 10

almost always anti-I and less commonly anti-i

Question 11

who does paroxysmal cold hemoglobinuria affect?

Answer 11

occurs in children who have had viral illness such as measles, mumps, chickenpox, infectious mononucleosis, and i’ll defined flu syndrome

Question 12

what is clinically significant about warm autoantibodies

Answer 12

they react best at 37C and about 70% of cases of AIHA are those that react best at warm temperatures

Question 13

What is drug induced immune hemolytic anemia?

Answer 13

when the antibody will only be reactive with RBCs in the presence of the drug

Question 14

What does Alpha methyl dopa do?

Answer 14

induces the production of an autoantibody that recognizes RBC antigens and alters the function of t suppresser cells and allows the production of antibodies against self

Question 16

What will you find in a smear when someone has warm autoimmune hemolytic anemia?

Answer 16

polychromasia and macrocytosis, reflecting reticulocytosis or even the presence of NRBCs

Question 17

RBC destruction occurring from sensitization with IgG antibody is primarily what?

Answer 17

extravascular

Question 18

you can determine a patients RBC phenotype using what?

Answer 18

either monoclonal antisera or by using the patients RBCs treated with chloroquine disphosphate to remove IgG immunoglobulins coating