Autoimmune Diseases Flashcards

1
Q

Goodpastures Disease

A

Type II
autoantibodies against type IV collagen of basement in glomerulus and alveoli
Glomerular nephritis (blood urine, decreased urine output)
Alveolar hemorrhages (bloody sputum/cough)
linear-smooth distribution of antibody upon staining

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Myasthenia Gravis

A
Type II 
Autoantibodies bind to AchR in NMJ
predominantly women
muscle weakness
Thymic hyperplasia*
Thymoma*
complement activation causes injury
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Graves Disease

A
Type II
Autoantibody that mimics TSH
Th2 mediated
low TSH, high T3/T4
Goiter
Hyperthroidism
Exophthalmos (protruding eyes)
predominantly women
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hashimoto Thyroiditis

A

Type II and type IV
Autoantibodies that block uptake of Iodine
Autoreactive CD4 T cells release TNFalpha
Th1 disease
mononuclear cellular infiltration of thyroid
Hypothyroidism
Thyroid distruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Scleroderma

A
Type II and IV (but systemic)
T cell involvement: pro-fibrotic cytokines
Autoantibodies: Topoisomerase I, Centromeres
small vessel obliterative disease
systemic fibrosis
Raynauds Phenomenon
Nucleoli staining
CREST
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Systemic Lupus Erythematosus (SLE)

A
Type III- Immune complex
Autoantibodies against dsDNA and Smith (RNA-protein complex)
women, African Americans
Malar Rash
Photosensitivity
Arthritis, Nephritis
Whole Nucleus staining
Globular staining of glomerulus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Rheumatic Arthritis

A
Type IV damage
Synovial Pannus
Rheumatic Factor
Anti-CCP
HLA-DR4
Rheumatic Nodules
Distorted joints
How well did you know this?
1
Not at all
2
3
4
5
Perfectly