Autoimmune disease Flashcards

1
Q

Lead marker for detection of RA

A

Anti CCP ( cyclic citrullinated peptide)

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2
Q

Antibody most specific for SLE

A

Anti-ds DNA

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3
Q

Ab specific for lupus associated with uridine rich RNA

A

Anti- smith (sm)

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4
Q

HLA associated with graves ds

A

HLA DR3 DR4 DQ

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5
Q

Formation of white plaques in the white matter of the brain and spinal cord, causing the destruction of myelin sheath of axons

A

Multiple sclerosis

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6
Q

Oligoclonal banding

A

Multiple sclerosis

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7
Q

Anti acetylcholine

A

Myesthenia gravis

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8
Q

Auto antibody that usually occurs after viral infection

A

Good pasteur syndrome

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9
Q

Anti basment antibodies

A

Good pasteur syndrome

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10
Q

T/F malignant cells undergo apoptosis

A

F

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11
Q

T/F malignant cells develop into mature cells

A

F

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12
Q

Most common humoral ab deficiency

A

Iga deficiency

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13
Q

Deficiency with NO BCELLS

A

Brutons X linked agammaglobulinemia

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14
Q

Bcells do not differentiate into plasma cells

A

Common variable deficiency

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15
Q

Catch 22

A

Di george syndrome

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16
Q

Underdeveloped thymus

A

Digeorge syndrome

17
Q

Defect in stemcell maturation

A

SCID

18
Q

Deficient adenosine deaminase

A

Scid

19
Q

Wasp gene

A

Wiskott aldrich syndrome

20
Q

Defect in kinase gene affecting the t & b cell

A

Ataxia telangiectasia

21
Q

Defective neutrophil chemotaxis

A

Jobs/igE deficiency

22
Q

3 E’s in jobs syndrome

A

Elevated IgE
Eczema
Eosinophilia

23
Q

Defect in CD40 ligand = prevents class switching

A

Hyper IgM syndrome

24
Q

Defective NADPH oxidase

A

CGD

25
Q

Diagnostic test for CGD

A

Nitroblue tetrazolium test

26
Q

Deficiency in chemotaxis that lacks CD 18

A

Leukocyte adhesion deficiency