Autoimmune disease Flashcards
1
Q
Autoimmune hemolytic anemia
A
- Rh blood group antigen, I antigen
2. Destruction of RBC by complement and phagocytes
2
Q
Autoimmune thrombocytopenia purpura
A
- Platelet integrin gpIIb:IIIa
2. Abnormal bleeding
3
Q
Goodpasture’s syndrome
A
- Non-collagenous domain of basement membrane collage type 4
- Glomerulonephritis, pulmonary hemorrhage
4
Q
Pemphigus vulgaris
A
- Epidermal cadherin
2. Skin blistering
5
Q
Pemphigus foliaceus
A
- Desmoglein
2. Mild skin blistering
6
Q
Acute rheumatic fever
A
- streptococcal cell wall antigen, cross react with cardiac m.
- Arthritis, myocarditis, scarring of heart valves
7
Q
Graves’ disease
A
- TSH hormone receptor
2. Hyperthyroidism
8
Q
Myasthenia gravis
A
- ACh receptor
2. Progressive weakness
9
Q
Type 2 diabetes
A
- Insulin receptor(antagonist)
2. Hyperglycemia, ketoacidosis
10
Q
Hypoglycemia
A
- Insulin receptor(agonist)
2. Hypoglycemia
11
Q
Pemphigus foliaceus
A
- Desmoglein
2. Mild skin blistering
