Autofluroescence

Question 1

What does increased autofluorescence suggest in relation to the RPE?

Answer 1

TPE dysfunction (increased metabolism
Loss of retinal photopigment and subretinal autofluorescent material

Question 2

What does decreased autofluorescence suggest in relation to the RPE?

Answer 2

RPE atrophy
Blockage of RPE cells

Question 3

What is lyonization?

Answer 3

X chromosome inactivated in woman

Results in X linked recessive traits being expressed

On autofluroescence lyonization diseases produce mottled appearance:

X linked ocular albinism
X linked RP
Low syndrome
Fabry disease

Question 4

Melanoma on autofluorescence

Answer 4

Orange lipofuscin pigment is autofluorescent
Recent leakage associated with increased autofluorescence

Question 5

Optic disc drusen

Answer 5

Increased autofluorescence

Question 6

Birdshot chorioreitnopathy

Answer 6

Reduced placoid autofluorescence

Autoimmune uveitis
HLA A29

Question 7

Best disease

Answer 7

Vitelliform material - increased autofluorescence

Inherited macular dystrophy

Question 8

What colour light for fundus camer autofluorescence

Answer 8

Gren light
Reduces lens interference

Better for detecting fluorphores in teh subreitnal space CSR

Question 9

What is scanning laser ophthalmoscopy

Answer 9

488nm exication filter
Reduces lens interference and scattered light

Infrared SLO uses 787nm excitation filter