autoantobodies Flashcards
1
Q
limited systemic sclerosis.
A
Anticentromere Ab
2
Q
Antiphospholipid Ab
A
antiphospholipid syndrome, SLE.
3
Q
Sjögren’s syndrome
A
Anti-Ro , Anti-La
4
Q
SLE
A
ANA
Anti-double-stranded DNA
Anti-Sm
Antiphospholipid Ab
5
Q
mixed connective tissue disease.
A
Anti-RNP
6
Q
Antihistone Ab
A
drug-induced SLE
7
Q
Polymyositis, dermatomyositis.
A
Anti Jo-1; Anti-Mi-2
8
Q
Diffuse systemic sclerosis.
A
Anti-Scl70
9
Q
HLA-DR24
A
Giant cell arteritis
10
Q
HLA B27
A
Ankylosing spondylitits
11
Q
Antimitochondrial Ab
A
Primary biliary cholangitis (>95%), Autoimmune hepatitis (30%), Idiopathic cirrhosis (25–30%).
12
Q
Anti-smooth muscle Ab
A
autoimmune hepatitis (70%) primary biliary cholangitis (50%) idiopathic cirrhosis (25–30%).
13
Q
Perinuclear (pANCA)
A
Myeloperoxidase (MPO +ve).
Microscopic polyangiitis (45%), Churg–Strauss
pulmonary-renal vasculitides (Goodpasture’s).
14
Q
Cytoplasmic cANCA
A
Granulomatosis with polyangiitis (Wegener’s)
15
Q
ANCA may also be +ve in what other condictions (not vasculitis related)
A
- UC/Crohn’s
- sclerosing cholangitis,
- autoimmune hepatitis
- Felty’s
- RA
- SLE
- drugs (eg antithyroid, allopurinol, ciprofloxacin).
