autoantobodies

Question 1

limited systemic sclerosis.

Answer 1

Anticentromere Ab

Question 2

Antiphospholipid Ab

Answer 2

antiphospholipid syndrome, SLE.

Question 3

Sjögren’s syndrome

Answer 3

Anti-Ro , Anti-La

Question 4

SLE

Answer 4

ANA
Anti-double-stranded DNA
Anti-Sm
Antiphospholipid Ab

Question 5

mixed connective tissue disease.

Answer 5

Anti-RNP

Question 6

Antihistone Ab

Answer 6

drug-induced SLE

Question 7

Polymyositis, dermatomyositis.

Answer 7

Anti Jo-1; Anti-Mi-2

Question 8

Diffuse systemic sclerosis.

Answer 8

Anti-Scl70

Question 9

HLA-DR24

Answer 9

Giant cell arteritis

Question 10

HLA B27

Answer 10

Ankylosing spondylitits

Question 11

Antimitochondrial Ab

Answer 11

Primary biliary cholangitis (>95%), 
Autoimmune hepatitis (30%), Idiopathic cirrhosis (25–30%).

Question 12

Anti-smooth muscle Ab

Answer 12

autoimmune hepatitis (70%)
primary biliary cholangitis (50%)
idiopathic cirrhosis (25–30%).

Question 13

Perinuclear (pANCA)

Answer 13

Myeloperoxidase (MPO +ve).
Microscopic polyangiitis (45%), Churg–Strauss
pulmonary-renal vasculitides (Goodpasture’s).

Question 14

Cytoplasmic cANCA

Answer 14

Granulomatosis
with polyangiitis (Wegener’s)

Question 15

ANCA may also be +ve in what other condictions (not vasculitis related)

Answer 15

• UC/Crohn’s
• sclerosing cholangitis,
• autoimmune hepatitis
• Felty’s
• RA
• SLE
• drugs (eg antithyroid, allopurinol, ciprofloxacin).

Question 16

myasthenia gravis

Answer 16

Ach receptor Ab

Question 17

Lambert–Eaton syndrome

Answer 17

Anti-voltage-gated Ca2+-channel Ab

Question 18

anti-CCP

Answer 18

RA

Question 19

Dermatomyositis antibodies?

Answer 19

anti-Jo1 &; anti-Mi2

80% ANA

Question 20

increase the risk of pregnancy loss and thrombosis

Answer 20

Antiphospholipid antibodies