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Boards Learn > Autoantibodies & Stains > Flashcards

Autoantibodies & Stains Flashcards

1
Q

SLE Auto AB’s?

A
  • ANA (nonspecific)
  • Anticardiolipin and lupus anticoagulant
  • Anti dsDNA, anti- smith
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2
Q

Anti- histone

A

Drug induced lupus

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3
Q

Anti U1 RNP (ribonucleoprotein)

A

mixed CT disease

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4
Q

RA?

A
  • Rheumatoid factor, an IgM Ab against IgG Fc region
  • Anti-CCP (more specific)
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5
Q

Anti-RO/SSA and Anti La/SSB?

A

Sjogren syndrome

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6
Q

Anti Scl70 (anti DNA topiosomerase I)

A

Scleroderma (diffuse)

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7
Q

Anticentromere

A

Limited scleroderma (CREST Syndrome)

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8
Q

Antisynthetase (anti Jo-1), Anti SRP, and Antihelicase (anti-Mi-2)?

A

Polymyositis and dermatomyositis

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9
Q

Autoimmune Hepatitis type 1

A

Anti smooth muscle

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10
Q

Primary biliary cholangitis?

A

Antimitochondrial

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11
Q

MPO-ANCA/ P-ANCA?

A
  • microscopic polyangiitis
  • Eosinophilic granulomatosis with polyangiitis
  • UC
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12
Q

GPA (wegner’s syndrome)

A

PR3-ANCA/c-ANCA

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13
Q

Primary membranous nephropathy?

A

Anti phospholipase A2 receptor

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14
Q

Bullous pemphigoid?

A

Anti-hemiddesmosome

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15
Q

Anti desmoglein (desmosome)

A

Pemphigus vulgaris

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16
Q

Anto g;utamic acid decarboxylase, islet cell cytoplasmic antibodies?

A

Type 1 DM

17
Q

Antiparietal cell and anti Intrinsic factor?

A

Pernicious anemia

18
Q

Anti GMB?

A

Good pasture syndrome

19
Q

Chromogranin and synaptophysin target and tumors identified?

A
  • Neuroendocrine cells
  • Small CC of lung and carcinoid tumor
20
Q

Cytokeratin stain target and tumors identified?

A
  • epitheial cells
  • epithelial tumors such as Squamous cell
21
Q

DesMin target and tumors identified?

A
  • Muscle
  • Muscle tumors (rhabdomyoscaroma)
22
Q

GFAP target and tumors identified?

A
  • neuroGlia
  • astrocytoma and Glioblastoma
23
Q

S-100 target and tumors identified?

A
  • neural crest cells
  • Melanoma, schwannoma, langerhands cell histiocytosis
24
Q

Vimentin target and tumors identified?

A
  • Mesenchymal tissue such as fibroblasts, endothelial cells and macrophages
  • Mesenchymal tumors (sarcomas), also endometrial and RCC, and mengioma

Boards Learn (6 decks)

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