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Immunology > Autoantibodies and associated disorders > Flashcards

Autoantibodies and associated disorders Flashcards

1
Q

Anti-postsynaptic ACh receptor

A

Myasthenia Gravis

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2
Q

Anti-presynaptic voltage gated calcium channel

A

Lambert- Eaton myasthenia syndrome

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3
Q

Anti- B2 glycoprotein I

A

Antiphospholipid syndrome

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4
Q

Antinuclear (ANA)

A

Nonspecific screening antibody, often associated with SLE

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5
Q

Anticardiolipin, Lupus anticoagulant

A

SLE, Antiphospholipid syndrome

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6
Q

Anti-dsDNA, Anti-Smith

A

SLE

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7
Q

Antihistone

A

Drug-induced lupus

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8
Q

Anti-U1 RNP (ribonucleoprotein)

A

Mixed connective tissue disease

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9
Q

Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific)

A

Rheumatoid arthritis

RF sensitive not specific
CCP is specific

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10
Q

Anti-Ro/SSA, anti-La/SSB

A

Sjögren syndrome

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11
Q

Anti-suck-70 (Anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

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12
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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13
Q

Antimitochondrial

A

Primary biliary cholangitis

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14
Q

Anti-smooth muscle

A

Autoimmune hepatitis type 1

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15
Q

MPO-ANCA/c-ANCA

A

Granulomatosis with polyangiitis (Wegener)

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16
Q

Anti-phospholipids A2 receptor

A

Primary membranous nephropathy

17
Q

Anti-hemidesmosome

A

Bulbous pemphigoid

18
Q

Anti-desmoglein (anti-desmosome)

A

Pemphigus vulgaris

19
Q

Antithyroglobulin, antithyroid peroxidase (antimicrosomal)

A

Hashimoto thyroiditis

20
Q

Anti-TSH receptor

A

Graves’ disease

21
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptide

A

Celiac disease

22
Q

Anti-glutamic acid decarboxylase, islet cell cytoplasmic antibody

A

Type 1 diabetes mellitus

23
Q

Antiparietal cell, anti-intrinsic factor

A

Pernicious anemia

24
Q

Anti-glomerular basement membrane

A

Good pasture syndrome

Immunology (1 decks)

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