Autoantibodies

Question 1

Anti-Scl-70 antibodies are specific for which condition?

Answer 1

Diffuse systemic sclerosis

Question 2

Which autoantibodies can be seen in anti-phospholipid syndrome?

Answer 2

Anti-cardiolipin antibodies and lupus anticoagulant

Question 3

Anti-Ro antibodies can be seen in which conditions?

Answer 3

SLE, Sjogren’s

Question 4

ANA is a very sensitive antibody but it is not very specific. Name some conditions it can be seen in?

Answer 4

SLE, Sjogren’s, systemic sclerosis, mixed connective tissue disease

Question 5

Which autoantibodies are specific for Sjogren’s syndrome?

Answer 5

Anti-La

Question 6

pANCA antibodies are seen in which condition? Which other antibodies may be seen in this condition?

Answer 6

EGPA (and MPA), also associated with anti-MPO

Question 7

Anti-dsDNA antibodies are specific for which condition?

Answer 7

SLE

Question 8

Anti-centromere antibodies are specific for which condition?

Answer 8

Limited systemic sclerosis

Question 9

cANCA antibodies are seen in which condition? Which other antibodies may be seen in this condition?

Answer 9

GPA, also associated with anti-PR3

Question 10

Anti-CCP antibodies are specific for which condition?

Answer 10

Rheumatoid arthritis

Question 11

Anti-Sm antibodies are mostly related to autoimmune hepatitis. It can however be associated with which rheumatological condition?

Answer 11

SLE

Question 12

Anti-Jo-1 antibodies are specific for which condition?

Answer 12

Myositis (i.e. polymyositis/dermatomyositis)