Autoantibodies Flashcards
What is rheumatoid factor (RhF) associated with?
- Sjogren’s syndrome (≤100%)
- Felty’s syndrome (≤100%)
- Rheumatoid arthritis (70%)
- Mixed connective tissue disease (50%)
- SLE (≤40%)
- Systemic sclerosis (30%)
- Normal (2-10%)
What is anticyclic citrullinated peptide Ab (anti-CCP) associated with?
Rheumatoid arthritis (96% specificity)
What is antinuclear antibody (ANA) associated with?
- SLE (>95%)
- Type I autoimmune hepatitis (75%)
- Sjogren’s syndrome (68%)
- Systemic sclerosis (96%)
- Rheumatoid arthritis (30%)
- Normal (0-2%)
What is associated with homogeneous immunofluorescence staining of ANA?
SLE
What is associated with speckled immunofluorescence staining of ANA
Mixed connective tissue disease
What is associated with nucleolar immunofluorescence staining of ANA?
Systemic sclerosis
What is associated with centromere immunofluorescence staining of ANA?
Limited systemic sclerosis
What is associated with anti-double-stranded DNA (dsDNA) antibodies?
SLE (60% sensitivity, but very high specificity)
What is associated with antihistone antibodies?
Drug-induced SLE (~100%)
What are anti-phospholipid antibodies?
- Lupus anticoagulant [LA]
- Anticardiolipin [aCL] antibodies
- Anti-β2-glycoprotein antibodies
What is associated with anti-phospholipid antibodies?
- Anti-phospholipid syndrome
- SLE
What is associated with anti-centromere antibodies?
Limited systemic sclerosis
What is associated with anti-Ro antibodies?
- SLE
- Sjogren’s syndrome
- Systemic sclerosis
What is associated with anti-Sm antibodies?
SLE (20-30%)
What is associated with anti-RNP antibodies?
- SLE
- Mixed connective tissue disease
What is associated with anti-Jo-1 and anti-Mi-2 antibodies?
- Polymyositis
- Dermatomyositis
What is associated with anti-Scl70 antibodies?
Diffuse systemic sclerosis
What is associated with anti-mitochondrial antibodies (AMA)?
- Primary biliary cholangitis (>95%)
- Autoimmune hepatitis (30%)
- Idiopathic cirrhosis (25-30%)
What is associated with anti-smooth muscle antibodies (ASMA)?
- Type I autoimmune hepatitis (70%)
- Primary biliary cholangitis (50%)
- Idiopathic cirrhosis (25-30%)
What is associated with anti-gastric parietal cell antibodies?
- Pernicious anaemia (>90%)
- Atrophic gastritis (40%)
- Normal (10%)
What is associated with anti-intrinsic antibodies?
Pernicious anaemia (50%)
Which autoantibodies are associated with coeliac disease?
- Anti-alpha-gliadin antibodies
- Anti-tissue transglutaminase antibodies
- Anti-endomysial antibodies
What is associated with anti-thyroid peroxidase antibodies?
- Hashimoto’s thyroiditis (~87%)
- Grave’s disease (>50%)
Which autoantibodies are associated with type I diabetes mellitus?
- Anti-islet cell antibodies (ICA)
- Anti-glutamic acid decarboxylase (GAD) antibodies
