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Clinical school: Rheumatology > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

What is rheumatoid factor (RhF) associated with?

A
  • Sjogren’s syndrome (≤100%)
  • Felty’s syndrome (≤100%)
  • Rheumatoid arthritis (70%)
  • Mixed connective tissue disease (50%)
  • SLE (≤40%)
  • Systemic sclerosis (30%)
  • Normal (2-10%)
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2
Q

What is anticyclic citrullinated peptide Ab (anti-CCP) associated with?

A

Rheumatoid arthritis (96% specificity)

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3
Q

What is antinuclear antibody (ANA) associated with?

A
  • SLE (>95%)
  • Type I autoimmune hepatitis (75%)
  • Sjogren’s syndrome (68%)
  • Systemic sclerosis (96%)
  • Rheumatoid arthritis (30%)
  • Normal (0-2%)
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4
Q

What is associated with homogeneous immunofluorescence staining of ANA?

A

SLE

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5
Q

What is associated with speckled immunofluorescence staining of ANA

A

Mixed connective tissue disease

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6
Q

What is associated with nucleolar immunofluorescence staining of ANA?

A

Systemic sclerosis

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7
Q

What is associated with centromere immunofluorescence staining of ANA?

A

Limited systemic sclerosis

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8
Q

What is associated with anti-double-stranded DNA (dsDNA) antibodies?

A

SLE (60% sensitivity, but very high specificity)

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9
Q

What is associated with antihistone antibodies?

A

Drug-induced SLE (~100%)

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10
Q

What are anti-phospholipid antibodies?

A
  • Lupus anticoagulant [LA]
  • Anticardiolipin [aCL] antibodies
  • Anti-β2-glycoprotein antibodies
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11
Q

What is associated with anti-phospholipid antibodies?

A
  • Anti-phospholipid syndrome
  • SLE
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12
Q

What is associated with anti-centromere antibodies?

A

Limited systemic sclerosis

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13
Q

What is associated with anti-Ro antibodies?

A
  • SLE
  • Sjogren’s syndrome
  • Systemic sclerosis
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14
Q

What is associated with anti-Sm antibodies?

A

SLE (20-30%)

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15
Q

What is associated with anti-RNP antibodies?

A
  • SLE
  • Mixed connective tissue disease
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16
Q

What is associated with anti-Jo-1 and anti-Mi-2 antibodies?

A
  • Polymyositis
  • Dermatomyositis
17
Q

What is associated with anti-Scl70 antibodies?

A

Diffuse systemic sclerosis

18
Q

What is associated with anti-mitochondrial antibodies (AMA)?

A
  • Primary biliary cholangitis (>95%)
  • Autoimmune hepatitis (30%)
  • Idiopathic cirrhosis (25-30%)
19
Q

What is associated with anti-smooth muscle antibodies (ASMA)?

A
  • Type I autoimmune hepatitis (70%)
  • Primary biliary cholangitis (50%)
  • Idiopathic cirrhosis (25-30%)
20
Q

What is associated with anti-gastric parietal cell antibodies?

A
  • Pernicious anaemia (>90%)
  • Atrophic gastritis (40%)
  • Normal (10%)
21
Q

What is associated with anti-intrinsic antibodies?

A

Pernicious anaemia (50%)

22
Q

Which autoantibodies are associated with coeliac disease?

A
  • Anti-alpha-gliadin antibodies
  • Anti-tissue transglutaminase antibodies
  • Anti-endomysial antibodies
23
Q

What is associated with anti-thyroid peroxidase antibodies?

A
  • Hashimoto’s thyroiditis (~87%)
  • Grave’s disease (>50%)
24
Q

Which autoantibodies are associated with type I diabetes mellitus?

A
  • Anti-islet cell antibodies (ICA)
  • Anti-glutamic acid decarboxylase (GAD) antibodies
25
Q

What is associated with anti-GBM antibodies?

A

Goodpasture’s syndrome

26
Q

What is associated with cANCA (specific for serine protease-3, PR3)?

A
  • Granulomatosis with polyangiitis (Wegener’s syndrome) (90%)
  • Micorscopic polyangiitis (30%)
  • Polyarteritis nodosa (11%)
27
Q

What is associated with pANCA (specific for myeloperoxidase, MPO)?

A
  • Mocroscopic polyangiitis (~45%)
  • Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
  • Goodpasture’s syndrome
28
Q

Aside from vasculitides, which other extra-vascular conditions may be +ve for ANCA (predominantly p-ANCA)?

A
  • IBD
  • Primary sclerosing cirrhosis
  • Autoimmune hepatitis
  • Felty’s syndome
  • Rheumatoid arthritis
  • SLE
  • Drugs (e.g. anti-thyroid, allopurinol, cprofloxacin)
29
Q

What is associated with anti-AChR antibodies?

A

Myasthenia gravis

30
Q

What is associated with anti-voltage gated potassium channel antibodies?

A

Limbic encephalitis

31
Q

What is associated with anti-VGCC antibodies?

A

Lambert-Eaton syndrome

32
Q

What is associated with anti-aquaporin 4 antibodies?

A
  • Neuromyelitis optica (Devic’s disease)
33
Q

Which autoantibodies are associated with type I autoimmune hepatitis?

A
  • Anti-smooth muscle antibodies (ASMA) (80%)
  • Anti-nuclear antibodies (ANA) (10%)
34
Q

Which autoantibodies are associated with type II autoimmune hepatitis?

A

Anti-liver/kidney microsomal type I (LKM1) antibodies

35
Q

What is associated with anti-endomysial antibodies?

A

Coeliac disease

Clinical school: Rheumatology (1 decks)

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