Autoantibodies

Question 1

What autoantibodies are associated with rheumatoid arthritis?

Answer 1

Rheumatoid factor

Anti-cyclic-citrullinated protein (anti-CCP)

Question 2

Which of the autoantibodies associated with rheumatoid arthritis is more specific?

Answer 2

Anti-CCP is more specific than rheumatoid factor

Anti-CCP is the preferred test

Question 3

What autoantibodies are associated with anti-phospholipid syndrome (APS)?

Answer 3

Anti-cariolipin
Anti-ß2 glycoprotein
Lupus anticoagulant

Question 4

What constitutes a positive test for anti-phospholipid syndrome autoantibodies?

Answer 4

Positive on 2 occasions 12 weeks apart

Question 5

What autoantibodies are associated with mixed connective tissue disease?

Answer 5

Anti-RNP

Question 6

What autoantibodies are associated with Sjogren’s syndrome?

Answer 6

Anti-Ro

Anti-La

Question 7

What autoantibodies are associated with systemic lupus erythematosus (SLE)?

Answer 7

Anti-nuclear antibody (ANA)

Anti-double stranded DNA (anti-dsDNA)

Question 8

What are the specificities and sensitivities of the auto-antibodies associated with systemic lupus erythematosus?

Answer 8

ANA

• high sensitivity (95% SLE patients positive)
• non-specific (1/5 general people positive)

If ANA negative, they don’t have SLE. If its positive, doesn’t mean they definitely have SLE.

Anti-dsDNA

• moderate specificity (60% SLE patents positive)
• high specificity

If anti-dsDNA positive, they definitely have SLE. If its negative doesn’t mean they definitely don’t have SLE

Question 9

What autoantibodies are associated with systemic sclerosis?

Answer 9

Anti-Scl-70

Anti-centromere

Question 10

What autoantibody is associated with diffuse systemic sclerosis?

Answer 10

Anti-Scl-70

Question 11

What auto-antibody is associated with limited systemic sclerosis?

Answer 11

Anti-centromere

Question 12

What auto-antibodies are associated with polymyositis?

Answer 12

Anti-Jo-1

Anti-SRP

Question 13

What auto-antibody is associated with eosinophilic granulomatosis with polyangiitis (EGPA)?

Answer 13

p-ANCA

MPO

Question 14

What auto-antibody is associated with granulomatosis with polyangiitis (GPA)?

Answer 14

c-ANCA

PR3

Question 15

Rheumatoid factor associated with ______

Answer 15

Rheumatoid arthritis

less specific than anti-CCP

Question 16

Anti-cyclic-citrullinated protein (anti-CCP) associated with ______

Answer 16

Rheumatoid arthritis

more specific than RF

Question 17

Anti-cardiolipin associated with _______

Answer 17

Anti-phospholipid syndrome

Question 18

Anti-ß2-glycoprotein associated with _______

Answer 18

Anti-phospholipid syndrome

Question 19

Lupus anticoagulant associated with _______

Answer 19

Anti-phospholipid syndrome

Question 20

Anti-RNP associated with ______

Answer 20

Mixed connective tissue disease

Question 21

Anti-Ro associated with _______

Answer 21

Sjogren’s syndrome

Question 22

Anti-La associated with _______

Answer 22

Sjogren’s syndrome

Question 23

Anti-nuclear antibody (ANA) associated with ______

Answer 23

Systemic lupus erythematosus

Question 24

Anti-double stranded DNA (anti-dsDNA) associated with ______

Answer 24

Systemic lupus erythematosus

Question 25

Anti-centromere associated with ________

Answer 25

Limited systemic sclerosis

Question 26

Anti-Scl-70 associated with ______

Answer 26

Diffuse systemic sclerosis

Question 27

Anti-Jo-1 associated with ______

Answer 27

Polymyositis

Question 28

Anti-SRP associated with _______

Answer 28

Polymyositis

Question 29

p-ANCA associated with _________

Answer 29

Eosinophilic granulomatosis with polyangiitis (EGPA)

Question 30

MPO associated with ________

Answer 30

Eosinophilic granulomatosis with polyangiitis (EGPA)

Question 31

c-ANCA associated with _________

Answer 31

Granulomatosis with polyangiitis (GPA)

Question 32

PR3 associated with ________

Answer 32

Granulomatosis with polyangiitis (GPA)