Autoantibodies

Question 1

Myastenia gravis

Answer 1

Anti-ACh receptor

Question 2

Goodpasture syndrome

Answer 2

Anti-basement membrane

Question 3

SLE and antiphospholipid syndrome

Answer 3

Anticardiolipin, lupus anticoagulant

Question 4

Limited scleroderma (CREST syndrome)

Answer 4

anticentromere

Question 5

Pemphigus vulgaris

Answer 5

anti-desmoglein (anti-desmosome)

Question 6

SLE

Answer 6

Anti-dsDNA and anti-Smith

Question 7

T1DM

Answer 7

Anti-glutamic acid decarboxylase (GAD-65)

Question 8

Bullous pemphigoid

Answer 8

anti-hemidesmosome

Question 9

Drug-Induced Lupus

Answer 9

Anti-histone

Question 10

Polymyositis, dermatomyositis

Answer 10

Anti-Jo-1
Anti-SRP
Anti-Mi-2

Question 11

Hashimoto thyroiditis

Answer 11

Anti-microsomal, antithyroglobulin

Question 12

Primary Biliary Cirrhosis

Answer 12

Antimitochondrial

Question 13

SLE (non-specific)

Answer 13

Antinuclear (ANA)

Question 14

Pernicious anemia

Answer 14

Antiparietal cell

Question 15

Primary Membranous Nephropathy

Answer 15

Antiphospholipase A2 receptor

Question 16

Scleroderma (diffuse)

Answer 16

Anti-Scl-70 (Anti-DNA topoisomerase I)

Question 17

Autoimmune Hepatitis Type 1

Answer 17

Anti-smooth muscle

Question 18

Sjogren syndrome

Answer 18

Anti-SSA, anti-SSB (Anti-Ro, Anti-La)

Question 19

Graves Dz

Answer 19

Anti-TSH receptor

Question 20

Mixed connective tissue dz

Answer 20

Anti-U1 RNP (ribonucleoprotein)

Question 21

Lambert-Eaton Syndrome

Answer 21

Voltage-gated calcium channel antibodies

Question 22

Celiac dz

Answer 22

IgA anti-endomysial, IgA anti-tissue transglutaminase

Question 23

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Answer 23

p-ANCA/MPO-ANCA

Question 24

Granulomatosis with polyangiitis (Wegener)

Answer 24

c-ANCA/PR3-ANCA

Question 25

Rheumatoid arthritis

Answer 25

``` Rheumatoid factor (IgM antibody that targets IgG Fc region) anti-CCP (more specific) ```