Autoantibodies Flashcards

1
Q

Myastenia gravis

A

Anti-ACh receptor

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2
Q

Goodpasture syndrome

A

Anti-basement membrane

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3
Q

SLE and antiphospholipid syndrome

A

Anticardiolipin, lupus anticoagulant

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4
Q

Limited scleroderma (CREST syndrome)

A

anticentromere

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5
Q

Pemphigus vulgaris

A

anti-desmoglein (anti-desmosome)

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6
Q

SLE

A

Anti-dsDNA and anti-Smith

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7
Q

T1DM

A

Anti-glutamic acid decarboxylase (GAD-65)

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8
Q

Bullous pemphigoid

A

anti-hemidesmosome

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9
Q

Drug-Induced Lupus

A

Anti-histone

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10
Q

Polymyositis, dermatomyositis

A

Anti-Jo-1
Anti-SRP
Anti-Mi-2

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11
Q

Hashimoto thyroiditis

A

Anti-microsomal, antithyroglobulin

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12
Q

Primary Biliary Cirrhosis

A

Antimitochondrial

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13
Q

SLE (non-specific)

A

Antinuclear (ANA)

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14
Q

Pernicious anemia

A

Antiparietal cell

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15
Q

Primary Membranous Nephropathy

A

Antiphospholipase A2 receptor

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16
Q

Scleroderma (diffuse)

A

Anti-Scl-70 (Anti-DNA topoisomerase I)

17
Q

Autoimmune Hepatitis Type 1

A

Anti-smooth muscle

18
Q

Sjogren syndrome

A

Anti-SSA, anti-SSB (Anti-Ro, Anti-La)

19
Q

Graves Dz

A

Anti-TSH receptor

20
Q

Mixed connective tissue dz

A

Anti-U1 RNP (ribonucleoprotein)

21
Q

Lambert-Eaton Syndrome

A

Voltage-gated calcium channel antibodies

22
Q

Celiac dz

A

IgA anti-endomysial, IgA anti-tissue transglutaminase

23
Q

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

A

p-ANCA/MPO-ANCA

24
Q

Granulomatosis with polyangiitis (Wegener)

A

c-ANCA/PR3-ANCA

25
Q

Rheumatoid arthritis

A
Rheumatoid factor (IgM antibody that targets IgG Fc region)
anti-CCP (more specific)