Autoantibodies

Question 1

Most SENSITIVE autoantibody for SLE

Answer 1

ANA

Question 2

anti-histone

Answer 2

Drug-induced lupus

Question 3

anti-RNP

Answer 3

Mixed connective tissue disease

Question 4

anti-centromere

Answer 4

CREST syndrome

Question 5

anti-Scl-70

Answer 5

Diffuse scleroderma

Question 6

anti-SSA (anti-Ro)

Answer 6

Sjogren syndrome

Question 7

anti-mitochondrial

Answer 7

Primary biliary cirrhosis

Question 8

anti-Saccharomyces

Answer 8

Crohn’s disease

Question 9

anti-TPO, anti-thyroglobulin

Answer 9

Hashimoto’s thyroiditis

Question 10

anti-proteinase-3 (C-ANCA)

Answer 10

Wegener’s granulomatosis

Question 11

anti-endothelial cell

Answer 11

Kawasaki disease

Question 12

anti-smooth muscle

Answer 12

Autoimmune hepatitis

Question 13

anti-cardiac muscle

Answer 13

Dressler syndrome

Question 14

anti-GBM

Answer 14

Goodpasture syndrome

Question 15

anti-cardiolipin

Answer 15

Antiphospholipid antibody syndrome

Question 16

anti-intrinsic factor

Answer 16

Pernicious anemia

Question 17

anti-adrenal

Answer 17

Addison’s disease

Question 18

Most SPECIFIC autoantibodies for SLE

Answer 18

1) anti-dsDNA

2) anti-Sm

Question 19

anti-myeloperoxidase (P-ANCA)

Answer 19

Churg-Strauss syndrome

Question 20

anti-endomysial

Answer 20

Celiac disease

Question 21

anti-TSH / anti-TSI

Answer 21

Graves disease

Question 22

anti-glutamate decarboxylase

Answer 22

T1DM autoimmune type (1a)