Autoantibodies Flashcards

1
Q

autoantibodies PSC

A

Autoantibodies: No antibodies are highly sensitive or specific to PSC. They aren’t very helpful in diagnosis but they can indicate where there is an autoimmune element to the disease that may respond to immunosuppression.
Antineutrophil cytoplasmic antibody (p-ANCA) in up to 94%
Antinuclear antibodies (ANA) in up to 77%
Anticardiolipin antibodies (aCL) in up to 63%

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1
Q

autoantibodies PBC

A

anti-mitochondrial antibodies (AMA) is most specific to PBC, anti-nuclear antibodies are present in 35% of patients

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2
Q

genetic associations rheumatoid arthritis

A

HLA DR4 (a gene often present in RF positive patients)

HLA DR1 (a gene occasionally present in RA patients)

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3
Q

auto-antibodies rheumatoid arthritis

A

Rheumatoid factor (RF) - positive in 70% of patients

Cyclic citrullinated peptide antibodies (anti-CCP) - more sensitive and specific than rheumatoid factor

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4
Q

best autoantibody test for rhuematoid arthritis

A

Cyclic citrullinated peptide antibodies (anti-CCP) - more sensitive and specific than rheumatoid factor

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5
Q

in what % of patients is RF positive

A

70%

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6
Q

auto-antibodies coeliac

A

anti-ttg = anti- tisue trasglutaminase

anti-ema = anti-endomysial

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7
Q

autoantibodies pernicious anaemia

A

Anti-intrinsic factor antibodies

Anti-parietal cell antibodies (to confirm/refute if anti-intrinsic antibodies negative)

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8
Q

autoantibodies assocuated with hashimotos hypothyroid

A

anti-thyroid peroxidase (anti-TPO) antibodies

and anti-thyroglobulin (anti-Tg) antibodies.

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9
Q

what things should you ask about to investigate vasculitis as the cause of mononeuritis multiplex

A
  • kidneys : going for a wee regularly? haematuria?
    check U&Es
  • skin: purpura,
  • respiratory: cough? sinusitis?
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10
Q

autoantibodies SLE

A

ANA - SENSITIVE - 85-99% will have positive - other things can make it positive. can be used effectively as rule out test

Anti-dsDNA - SPECIFIC 50% will have positive - specific

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11
Q

autoantibodies systemic sclerosis

A

ANA positive in 90%
RF positive in 30%

anti-scl-70 antibodies associated with diffuse cutaneous systemic sclerosis

anti-centromere antibodies associated with limited cutaneous systemic sclerosis

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