Autoantibodies Flashcards
autoantibodies PSC
Autoantibodies: No antibodies are highly sensitive or specific to PSC. They aren’t very helpful in diagnosis but they can indicate where there is an autoimmune element to the disease that may respond to immunosuppression.
Antineutrophil cytoplasmic antibody (p-ANCA) in up to 94%
Antinuclear antibodies (ANA) in up to 77%
Anticardiolipin antibodies (aCL) in up to 63%
autoantibodies PBC
anti-mitochondrial antibodies (AMA) is most specific to PBC, anti-nuclear antibodies are present in 35% of patients
genetic associations rheumatoid arthritis
HLA DR4 (a gene often present in RF positive patients)
HLA DR1 (a gene occasionally present in RA patients)
auto-antibodies rheumatoid arthritis
Rheumatoid factor (RF) - positive in 70% of patients
Cyclic citrullinated peptide antibodies (anti-CCP) - more sensitive and specific than rheumatoid factor
best autoantibody test for rhuematoid arthritis
Cyclic citrullinated peptide antibodies (anti-CCP) - more sensitive and specific than rheumatoid factor
in what % of patients is RF positive
70%
auto-antibodies coeliac
anti-ttg = anti- tisue trasglutaminase
anti-ema = anti-endomysial
autoantibodies pernicious anaemia
Anti-intrinsic factor antibodies
Anti-parietal cell antibodies (to confirm/refute if anti-intrinsic antibodies negative)
autoantibodies assocuated with hashimotos hypothyroid
anti-thyroid peroxidase (anti-TPO) antibodies
and anti-thyroglobulin (anti-Tg) antibodies.
what things should you ask about to investigate vasculitis as the cause of mononeuritis multiplex
- kidneys : going for a wee regularly? haematuria?
check U&Es - skin: purpura,
- respiratory: cough? sinusitis?
autoantibodies SLE
ANA - SENSITIVE - 85-99% will have positive - other things can make it positive. can be used effectively as rule out test
Anti-dsDNA - SPECIFIC 50% will have positive - specific
autoantibodies systemic sclerosis
ANA positive in 90%
RF positive in 30%
anti-scl-70 antibodies associated with diffuse cutaneous systemic sclerosis
anti-centromere antibodies associated with limited cutaneous systemic sclerosis