Auto immune disease

Question 1

What are the syptoms of SLE?

Answer 1

Photosensitve malar rash
Multiple mouth ulcers
Athralgia (pain in joints)
Alopecia

Question 2

Pathology of SLE?

Answer 2

• immune system forms antibodies against proteins/DNA in the nuclei of cells
• anti-nuclear antibodies bind to skin damaged by UV light
• anti-nuclear antibodies plus antigens = immune complex
• these immune complexes can cause inflammation in ANY tissue

Question 3

Test for Lupis?

Answer 3

Test for anti nuclear antibodies (ANAs)

Question 4

What is ANCA vasculitis?

Answer 4

Inflammation of vessels caused by ANCA (anti neutrophil cytoplasmic antibodies).
All have polyangitis
Some have granulomata also

Question 5

Most imortant type of ANCA vasculitis?

Answer 5

Wegener’s granulomatosis (WG), is a systemic disorder that involves both granulomatosis and polyangiitis.

Question 6

What is the test for ANCA vasculitis?

Answer 6

Test for ANCA

Question 7

Treatment for ANCA vasculitis?

Answer 7

Immune surpression

Question 8

What is the pathology of Pernicious anaemia?

Answer 8

AI blocks intrinsic factor

Parietal cells cant absorb B12 anymore

Question 9

What kind of anaemia does pernicious aneamia cause/is?

Answer 9

Macrocytic anaemia

Question 10

What is the pathology of Myasthenia gravis?

Answer 10

Auto antibodies block ACH receptor

Question 11

What is often swollen in MG?

Answer 11

Thymus gland - if remove it can be cured (apparently although i doubt this)

Question 12

What are the two types of Raynauds?

Answer 12

Primary and secondary

Question 13

Tell me about primary Reynauds

Answer 13

Harmless
Young women
ANA negative

Question 14

Tell me about secondary Raynauds?

Answer 14

ANA positive

Can be ascosiated with scleredoma

Question 15

What does Graves disease cause?

Answer 15

Hyperthyroidism

Question 16

What does Hashmitos cause?

Answer 16

HYpothyroidism

Question 17

How does Graves works?

Answer 17

Anti TSH antibody

get low TSH high t3 t4

Question 18

What can make proteins more immunogenic?

Answer 18

Citrullination

Question 19

What is coeliac disease?

Answer 19

Anti-transglutaminase antibodies to the enzyme tissue transglutaminase (tTG) are found in the blood of the majority of people with classic symptoms

Question 20

What is the difference between autoinflammation and auto immunity?

Answer 20

AI

• b cells and t cells
• autoantibodies present
• continuous progression
• therapy = anti b/t cell

Auto inflam

• neutrophils and macrophages
• thereapy = anti cytokine
• no auto antibodies