Auto antibody screen Flashcards
1
Q
What is the auto antibody screen
A
Indirect immunofluorescent detection of autoantibodies to rat liver/kidney/stomach substrates on commercially prepared slides
2
Q
What types of antibodies does the screen detect
A
Anti-parietal cell (PCAs)
Anti-mitochondrial (AMAs)
Anti-smooth muscle (SMAs)
Anti-nuclear
3
Q
How is the screen carried out?
A
By hand or on the Helmet analyser
4
Q
When might PCAs be seen
A
Seen in 80% of pernicious anaemias
5
Q
When might AMAs be seen
A
Liver diseases e.g. primary billiary cirrhosis
6
Q
When might smooth muscle antibodies be seen
A
Chronic active hepatitis
Primary billiary cirrhosis
7
Q
A
