Auto-Antibodies and Rheumatic Markers Flashcards
1
Q
Anti-histone
A
Drug induced lupus
2
Q
ANA
A
SLE (95%) Drug induced lupus (100%) Mixed connective tissue disease (95%) Sjogren's (70%) Scleroderma/CREST (80%) Dermatomyositis/polymyositis (80%) RA (50%)
3
Q
Anti-ds DNA
A
SLE (60%)
Sjogren’s (30%)
4
Q
Anti-Sm
A
SLE (40%)
5
Q
Anti-Ro/La (SS-A/SS-B)
A
SLE (40%) and neonatal lupus
Sjogren’s (50%)
6
Q
Anti-leucine aminopeptidase
A
Sjogren’s (60%)
SLE (15%)
7
Q
Anti-scl-70 (antitopoisomerase I)
A
Scleroderma (20%)
CREST (10%)
8
Q
Anti-centromere
A
Scleroderma (30%)
CREST (80%)
9
Q
RF
A
RA (70%)
10
Q
C-ANCA
A
Wegener’s granulomatosis
11
Q
P-ANCA
A
Polyarteritis nodosa
Churg-Strauss Syndrome
12
Q
Lupus anticoagulant
A
Antiphospholipid antibody syndrome
13
Q
Anti-uroporphyrin isomerase ribonucleoprotein (anti-U1-RNP)
A
Mixed connective tissue disease (90%) SLE (40%) Scleroderma (15%) Dermatomyositis/polymyositis (15%) CREST (10%)
14
Q
Anti-Jo-1 (antisynthetase)
A
Dermatomyositis/polymyositis
15
Q
Anti-signal recognition particle
A
Dermatomyositis/polymyositis