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Rheumatology and Vasculitides > Auto-Antibodies and Rheumatic Markers > Flashcards

Auto-Antibodies and Rheumatic Markers Flashcards

1
Q

Anti-histone

A

Drug induced lupus

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2
Q

ANA

A 
SLE (95%)
Drug induced lupus (100%)
Mixed connective tissue disease (95%)
Sjogren's (70%)
Scleroderma/CREST (80%)
Dermatomyositis/polymyositis (80%)
RA (50%)
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3
Q

Anti-ds DNA

A

SLE (60%)

Sjogren’s (30%)

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4
Q

Anti-Sm

A

SLE (40%)

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5
Q

Anti-Ro/La (SS-A/SS-B)

A

SLE (40%) and neonatal lupus

Sjogren’s (50%)

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6
Q

Anti-leucine aminopeptidase

A

Sjogren’s (60%)

SLE (15%)

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7
Q

Anti-scl-70 (antitopoisomerase I)

A

Scleroderma (20%)

CREST (10%)

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8
Q

Anti-centromere

A

Scleroderma (30%)

CREST (80%)

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9
Q

RF

A

RA (70%)

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10
Q

C-ANCA

A

Wegener’s granulomatosis

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11
Q

P-ANCA

A

Polyarteritis nodosa

Churg-Strauss Syndrome

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12
Q

Lupus anticoagulant

A

Antiphospholipid antibody syndrome

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13
Q

Anti-uroporphyrin isomerase ribonucleoprotein (anti-U1-RNP)

A 
Mixed connective tissue disease (90%)
SLE (40%)
Scleroderma (15%)
Dermatomyositis/polymyositis (15%)
CREST (10%)
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14
Q

Anti-Jo-1 (antisynthetase)

A

Dermatomyositis/polymyositis

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15
Q

Anti-signal recognition particle

A

Dermatomyositis/polymyositis

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16
Q

Anti-Mi-2

A

Dermatomyositis/polymyositis

17
Q

HLA-B27

A

Ankylosing spondylitis
Reiter’s syndrome/Reactive arthritis
Psoriatic arthritis

18
Q

HLA-DR2

19
Q

HLA-DR3

A

SLE

Sjogren’s

20
Q

HLA-DR4

21
Q

Anti-citrullinated peptide/protein (ACPA)

22
Q

Anti-mitochondrial antibodies

A

Primary biliary cirrhosis

23
Q

Anti-SMA

A

Autoimmune hepatitis

24
Q

Anti-glomerular basement membrane antibody

A

Goodpasture’s syndrome

25
Q

Glutamic acid decarboxylase antibodies

26
Q

Acetylcholine receptor antibodies

A

Myasthenia gravis

27
Q

Anti-TPO

A

Graves disease

Rheumatology and Vasculitides (2 decks)

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