Auto antibodies

Question 1

Anti-Ach receptor

Answer 1

Myasthenia

Question 2

Anti-basement membrane

Answer 2

Goodpasture

Question 3

Anti-cardiolipin

Answer 3

SLE, antiphospholipid

Question 4

Anticentromere

Answer 4

CREST

Question 5

Anti-desmoglein

Answer 5

Pemphigus

Question 6

Anti-ds DNA

Answer 6

SLE

Question 7

Anti-glutamate decarboxylase

Answer 7

Type 1 DM

Question 8

Anti-hemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Antihistone

Answer 9

Drug-induced lupus

Question 10

Anti-Jo, Anti-Mi, Anti-SRP (anti-histidyl-tRNA synthetase)

Answer 10

Polymyositis, dermatomyositis

Question 11

antimicrosomal, antithyroglbulin

Answer 11

hashimoto

Question 12

Antimitchondrial

Answer 12

primary biliary cirrhosis

Question 13

Anti DNA topoisomerase 1

Answer 13

Scleroderma (Anti-Scl-70)

Question 14

Anti-smooth muscle

Answer 14

Autoimmune hepatitis

Question 15

Anti-Ro, Anti-La (anti-nuclear)

Answer 15

Sjogren

Question 16

Anti-TSH

Answer 16

Graves

Question 17

Anti ribonucleoprotein

Answer 17

Mixed connective tissue disease - SLE + CREST + Polymyositis

Question 18

IgA antiendomysial, anti-transglutaminase

Answer 18

Celiac

Question 19

PR3-ANCA

Answer 19

Granulomatosis with polyangiitis

Question 20

MPO-ANCA

Answer 20

Microscopic polyangiitis, churg-strauss

Question 21

IgM to Fc of IgG, anti-CCP

Answer 21

Rheumatoid

Question 22

Lupus anticoagulant

Answer 22

Antiphospholipid syndrome - Elevated PTT w/increased clotting and spontaneous abortions - False positive VDRL

Rx: Anticoagulate patient