Auto-antibodies

Question 1

Anti-ACh receptor

Answer 1

Myesthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anti-cardiolipin, lupus anticoagulant

Answer 3

SLE, anti phospholipid syndrome

Question 4

Anti-centromere

Answer 4

CREST, limited schleroderma

Question 5

Anti-desmosome

Answer 5

Pemphigus vulgaris

Question 6

Anti-hemidesmosome

Answer 6

Bullous pemphigoid

Question 7

Anti-glutamic acid decarboxylase (GAD-65)

Answer 7

Type I DM

Question 8

Anti-dsDNA, anti-Smith

Answer 8

SLE

Question 9

Anti-histone

Answer 9

Drug-induced lupus

Question 10

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 10

Polymyositis, dermatomyositis

Question 11

Anti-microsomal, anti-thyroglobulin

Answer 11

Hashimoto thyroiditis

Question 12

Antimitochondrial

Answer 12

PBC

Question 13

ANA

Answer 13

SLE, non-specific

Question 14

Anti-parietal cell

Answer 14

Pernicious anemia

Question 15

Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 15

Scleroderma)

Question 16

Anti-smooth muscle

Answer 16

Autoimmune hepatitis (PSC)

Question 17

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 17

Sjogren syndrome

Question 18

Anti-TSH Receptor

Answer 18

Graves disease

Question 19

Anti-U1 RNP (ribonucleoprotein)

Answer 19

Mixed connective tissue disease

Question 20

IgA anti-endomysial, IgA anti-tissue transglutaminase (TTG)

Answer 20

Celiac disease

Question 21

MPO-ANCA/p-ANCA

Answer 21

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Question 22

PR3-ANCA/c-ANCA

Answer 22

GPA (Wegener)

Question 23

Rheumatoid factor (IgM ab targeting IgG Fc region), anti-CCP (more specific)

Answer 23

Rheumatoid arthritis