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CORE 2022 > Auto-antibodies > Flashcards

Auto-antibodies Flashcards

1
Q

Anti-nuclear Antibody

A
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2
Q

ssDNA

A
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3
Q

c1q

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4
Q

Cardiolipin

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5
Q

Centromere

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6
Q

dsDNA

A

Presence of high-titer anti–double-stranded (DS) antibodies is not specific for drug-induced lupus, with the exception of systemic lupus erythematosus (SLE) induced by anti–tumor necrosis factor (TNF) agents (adalimumab, infliximab, and etanercept). In anti–TNF agent induced SLE, anti-DSDNA antibodies may be present in up to 90% of the cases. Some patients who develop anti–TNF agent induced lupus have been successfully switched to a different anti–TNF agent without recurrence.

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7
Q

Histone

A
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8
Q

Ku

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9
Q

La/SSB

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10
Q

a-fodrin

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11
Q

MDA5/CADM-140

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12
Q

Mi-2

A

Classic: gottron papules, gottron sign, shawl sign

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13
Q

p140

A

2 malignant adult

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14
Q

p155

A

Anti-TIF1 antibodies are associated with severe photosensitive cutaneous findings, palmar hyperkeratosis, psoriasiform dermatitis, and the development of solid and hematologic malignancies.

Also associated w/ cutaneous symptoms (heliotrope, Gottron’s, flagellate erythema)

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15
Q

RNA polymerase

A
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16
Q

Ro/SSA

A

Also seen in SCLE w/ photosensitivity

17
Q

rRNP

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18
Q

Scl-70

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19
Q

Smith

A
20
Q

SRP

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DM - severe proximal muscle weakness

21
Q

Synthetase

A
22
Q

U1RNP

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23
Q

ECM1 (extracellular matrix protein 1)

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Lichen sclerosis (correlates with disease activity)

24
Q

Myositis antibodies

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25
Q

Jo1

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Target: directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis

Dermatomyositis with pulmonary fibrosis, Raynaud’s, polyarthritis

26
Q

Complement deficiencies

A

CORE 2022 (6 decks)

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