Autacoids Flashcards
long acting 1st gen H1 blockers
Meclizine and hydroxyzine
Most anticholinergic effects and uses
Promethazine>Diphenhydramine>dimenhydrinate
EPS,Menieres disease,Motion sickness
Topical route 1st gen agents
Doxepin,Diphenhydramine
Intravenous 1st gen
diphenhydramine,chlorpheniramine,hydroxyzine
Local anesthetis effects of 1st gen
diphenhydramine and promethazine
DOC in morning sickness
Doxylamine with pyridoxine
1st gen used as TCA
DOxepin due to its monoamine reuptake inhibitor mechanism
Least sedating 1st gen drug
cHLORPHENIRAMINE preferred for day time use
1st gen drug causing weight gain
cyproheptadine
derivatives
Hydroxyzine
Loratadine
Terfenadine
CEtrizine
Desloratadine
Fexofenadine
Most sedating 2nd gen drug
Least sedating
cetrizine
Fexofendaine
Longest acting
Fastest acting
Astemizole
terfenadine-Can cause qt prolongation
Order of potency of 2nd gen drugs
Desloaratadine>Levocetrizine>cetrizine
excreted by liver
fexofenadine
excreted by kidney
loratadine and cetrizine
2nd gen drug having PAF blocking property used in post cabg
Rupatadine
Topical route 2nd gen agents
Olopatadine
azelastine intanasal preparation
Uses of H1 blockers
ALlegric rhinits
non allergic rhinits
and in urticaria
H1 receptor site and actions
Postsynaptic
Gq acts by increasing calcium concentration
H2 receptor site and actions
postsynaptic
Gs increases cAMP
H3 receptor sites and actions
presynaptic
decreases histamine release therfore causinf=g decreasded actions of h1 and h2
H4
Leucocytes and causes chemotaxis
