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Pharmacology > Autacoids > Flashcards

Autacoids Flashcards

1
Q

long acting 1st gen H1 blockers

A

Meclizine and hydroxyzine

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2
Q

Most anticholinergic effects and uses

A

Promethazine>Diphenhydramine>dimenhydrinate

EPS,Menieres disease,Motion sickness

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3
Q

Topical route 1st gen agents

A

Doxepin,Diphenhydramine

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4
Q

Intravenous 1st gen

A

diphenhydramine,chlorpheniramine,hydroxyzine

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5
Q

Local anesthetis effects of 1st gen

A

diphenhydramine and promethazine

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6
Q

DOC in morning sickness

A

Doxylamine with pyridoxine

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7
Q

1st gen used as TCA

A

DOxepin due to its monoamine reuptake inhibitor mechanism

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8
Q

Least sedating 1st gen drug

A

cHLORPHENIRAMINE preferred for day time use

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9
Q

1st gen drug causing weight gain

A

cyproheptadine

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10
Q

derivatives
Hydroxyzine
Loratadine
Terfenadine

A

CEtrizine
Desloratadine
Fexofenadine

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11
Q

Most sedating 2nd gen drug

Least sedating

A

cetrizine

Fexofendaine

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12
Q

Longest acting

Fastest acting

A

Astemizole

terfenadine-Can cause qt prolongation

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13
Q

Order of potency of 2nd gen drugs

A

Desloaratadine>Levocetrizine>cetrizine

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14
Q

excreted by liver

A

fexofenadine

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15
Q

excreted by kidney

A

loratadine and cetrizine

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16
Q

2nd gen drug having PAF blocking property used in post cabg

A

Rupatadine

17
Q

Topical route 2nd gen agents

A

Olopatadine

azelastine intanasal preparation

18
Q

Uses of H1 blockers

A

ALlegric rhinits
non allergic rhinits
and in urticaria

19
Q

H1 receptor site and actions

A

Postsynaptic

Gq acts by increasing calcium concentration

20
Q

H2 receptor site and actions

A

postsynaptic

Gs increases cAMP

21
Q

H3 receptor sites and actions

A

presynaptic

decreases histamine release therfore causinf=g decreasded actions of h1 and h2

22
Q

H4

A

Leucocytes and causes chemotaxis

Pharmacology (2 decks)

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