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Pharmacology > Autacoids > Flashcards

Autacoids Flashcards

1
Q

Histamine receptors: H1R

A

Distribution: airway smooth muscle
Post receptor mechanism: Gq, ⬆️IP3, DAG
Function: ⬆️pruritus, pain, bronchoconstriction

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2
Q

Histamine receptor: H2R

A

Distribution: GI mucosa, heart muscle, mast cell
Post receptor mechanism: Gs, ⬆️ CAMP
Function: gastric acid production

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3
Q

Histamine receptor: H3

A

Distribution: brain
Post receptor mechanism: Gi, ⬇️CAMP
Function: ⬆️pruritus

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4
Q

Histamine receptor: H4R

A

Distribution: CD4 T cells
Post receptor mechanism: Gi, ⬇️ CAMP
Function: ⬆️pruritus

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5
Q

H1 blocker effects

A

Sedation
Anti nausea anti emetic
Anti muscarinic
Anti parkinson

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6
Q

Chlorphenamine

A

Paradoxical cns stimulation in children

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7
Q

Diphenhydramine, clemastine

A

Marked sedation, anti motion sickness

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8
Q

2nd generation h1 blockers

A 
Cetirizine
Fexofenadine
Loratadine
Desloratadine
Ebastine
Levocabastine
Azelastine
Olopatadine
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9
Q

PK of h1 blockers

A

Most are well absorbed orally

Peak 1-3 hrs after administration

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10
Q

Indications for antihistamine

A 
Allergic rhinitis 
Allergic conjunctivitis
Urticaria
Atopic dermatitis
Prophylaxis anti motion sickness
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11
Q

Adverse effects anti histamine

A

Cns depressive: fatigue, weakness
Cns stimulating: insomnia, irritability
Dry mouth
Less gi motility

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12
Q

Astemizole and terfenadine

A

⬆️QT interval (torsades de pointes)

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13
Q

Serotonin

A

Metabolized by MAO

Regulation of mood, sleep, temp control, vomitting, pain perception

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14
Q

Source of ergot alkaloid

A

Claviceps purpurea

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15
Q

Ergot alkaloids toxicity

A

Gi: diarrhea, vomitting

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16
Q

Vasoactive peptides: constrictors

A 
Angiotensin 2
Vasopressin
Endothelin
Neuropeptide y
Urotensin
17
Q

Vasoactive peptide dilators

A 
Bradykinins
Natriuretic peptide
Vasoactive peptide
Substance p
Neurotensin
Calcitonin gene related peptide
18
Q

Which angiotensin receptor has affinity for losartan?

A

AT 1

19
Q

AT 1 site

A

Vascular tissues

20
Q

AT 2 site

A

Fetal tissues

21
Q

Moa of ACE INHIBITORS

A

Blocks conversion of ang 1 to ang 2

22
Q

Aliskiren moa

A

Inhibit renin action on angiotensinogen

23
Q

Maintain Patency of ductus arteriosus in cyanogic congenital heart disease

A

Alprostadil

24
Q

Cytoprotective for peptic ulcer

A

Misoprostol

25
Q

Open angle glaucoma

A

Latanoprost

26
Q

Pulmonary hpn

A

Epoprostenol

27
Q

Buspirone

A

Anxiety, depression

28
Q

Sumatriptan

A

Acute migraine

29
Q

Phenoxybenzamine

A

Pheomochromocytoma

30
Q

Cyproheptadine

A

Carcinoid syndrome

31
Q

Ketanserin

A

Hpn

32
Q

Ondansetron

A

Prevention of nausea and vomitting in surgery and cancer chemo

33
Q

Cisapride

A

Gerd

34
Q

Tegaserod

A

Irritable bowel syndrome and constipation

35
Q

Bromocriptine

A

Dopamine

Lower prolactin

36
Q

Ergonovine

A

Alpha adrenoreceptor and 5ht2

Control of late uterine bleeding

37
Q

Ergotamine

A

5ht2

Migraine

Pharmacology (3 decks)

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