Autacoids

Question 1

Biogenic amines

Answer 1

Histamine

Serotonin

Question 2

Storage site of histamine

Answer 2

Mast cells

Basophils

Question 3

Release if histamine

Answer 3

Immunologic
Chemical
Mechanical/ physical injury- mast cell damage

Question 4

4 types GPCR

Answer 4

H1-gq
H2-Gs
H3- Gi
H4-Gi

Question 5

Ethanolamines- marked sedation

Answer 5

Diphenhydramine
Dimenhydrinate
Doxylamine

Question 6

Piperazine

Answer 6

Hydroxyzine

Meclizine

Question 7

Phenothiazines

Answer 7

Promethazine

W/ alpha adrenergic block, marked sedation, used as antiemetics

Question 8

Alkylamines

Answer 8

Chlorphenamine- chlortrimethon

Less sedation and drownsinessb

Question 9

Piperidine

Answer 9

Fexofenadine

Metabolite of terfenadine, has no arrhythmogenic potential

Question 10

Phthalazine

Answer 10

Azelastine

Oral and topical

Question 11

Treat,ent allergic rhinitis

Answer 11

Oral:1st or 2nd gen (+/-) decogestant

Question 12

Allergic conjuctivitis

Answer 12

Azelastine phthalmic eye drops

Question 13

DOC Anaphylaxis,Asthma

Answer 13

Epinephrine

Question 14

Used to abort migrain attacks, not prophylaxis

Answer 14

Triptans

Question 15

Stimulate smoth ms 5 HT2

Answer 15

Ergonovine- synthetic
Methylergonovine
Given after delivery of placenta
To control and prevent postpartum bleeding
Prevent or treat uterine atony

Question 16

Partial agonist at prejunctional neuronal 5HT2 receptors

Answer 16

Ergotamine, dihydroergotamine

Question 17

Prostaglandin analogue which prevents gastric ulcers due to NSAID therapy

Answer 17

Misoprostol
Stimulates uterine contraction
Abortifacient

Question 18

Stimulate uterine contractions, terminate pregnancy at any stage, great postpartum bleeding

Answer 18

Dinoprostone

Latanoprost

Question 19

PGF 2a derivatives

Answer 19

Latanoprost

Carboprost

Question 20

Maintains patency of ductus arteriosus after birth

Treat erectile dysfunction

Answer 20

Alprostadil PGE1
Congenital cardiac anomalies: transposition great vs, pulmonary atresia, stenosis
For erection- urethral suppository (MUSE) 2 pellets in 24h

Question 21

Stimulates guanidyl cyclase- CGMP- phophorlation of proteins

Answer 21

NO

Question 22

Nitric oxide donors

Answer 22

Organic nitrates
Organic nitrites
Sodium nitroprusside
NO gas inhalation

Question 23

No cGMP pathway enhancers

Answer 23

PDE-5 inhibitors

Question 24

Most acceptable for patients for erectile dysfunction

Answer 24

PDE5 inhibitors

Question 25

Drawback of alprostadil

Answer 25

Invasive
Produce pain
High risk of priapism

Question 26

Long acting PDE inhibitors

Answer 26

Tadalafil-Cialis

Question 27

Adv effect impaired color discrimination

Answer 27

PDE 6 inhibitors