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Pharmacology > Autacoids > Flashcards

Autacoids Flashcards

1
Q

Biogenic amines

A

Histamine

Serotonin

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2
Q

Storage site of histamine

A

Mast cells

Basophils

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3
Q

Release if histamine

A

Immunologic
Chemical
Mechanical/ physical injury- mast cell damage

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4
Q

4 types GPCR

A

H1-gq
H2-Gs
H3- Gi
H4-Gi

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5
Q

Ethanolamines- marked sedation

A

Diphenhydramine
Dimenhydrinate
Doxylamine

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6
Q

Piperazine

A

Hydroxyzine

Meclizine

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7
Q

Phenothiazines

A

Promethazine

W/ alpha adrenergic block, marked sedation, used as antiemetics

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8
Q

Alkylamines

A

Chlorphenamine- chlortrimethon

Less sedation and drownsinessb

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9
Q

Piperidine

A

Fexofenadine

Metabolite of terfenadine, has no arrhythmogenic potential

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10
Q

Phthalazine

A

Azelastine

Oral and topical

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11
Q

Treat,ent allergic rhinitis

A

Oral:1st or 2nd gen (+/-) decogestant

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12
Q

Allergic conjuctivitis

A

Azelastine phthalmic eye drops

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13
Q

DOC Anaphylaxis,Asthma

A

Epinephrine

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14
Q

Used to abort migrain attacks, not prophylaxis

A

Triptans

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15
Q

Stimulate smoth ms 5 HT2

A 
Ergonovine- synthetic
Methylergonovine
Given after delivery of placenta
To control and prevent postpartum bleeding
Prevent or treat uterine atony
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16
Q

Partial agonist at prejunctional neuronal 5HT2 receptors

A

Ergotamine, dihydroergotamine

17
Q

Prostaglandin analogue which prevents gastric ulcers due to NSAID therapy

A

Misoprostol
Stimulates uterine contraction
Abortifacient

18
Q

Stimulate uterine contractions, terminate pregnancy at any stage, great postpartum bleeding

A

Dinoprostone

Latanoprost

19
Q

PGF 2a derivatives

A

Latanoprost

Carboprost

20
Q

Maintains patency of ductus arteriosus after birth

Treat erectile dysfunction

A

Alprostadil PGE1
Congenital cardiac anomalies: transposition great vs, pulmonary atresia, stenosis
For erection- urethral suppository (MUSE) 2 pellets in 24h

21
Q

Stimulates guanidyl cyclase- CGMP- phophorlation of proteins

A

NO

22
Q

Nitric oxide donors

A

Organic nitrates
Organic nitrites
Sodium nitroprusside
NO gas inhalation

23
Q

No cGMP pathway enhancers

A

PDE-5 inhibitors

24
Q

Most acceptable for patients for erectile dysfunction

A

PDE5 inhibitors

25
Q

Drawback of alprostadil

A

Invasive
Produce pain
High risk of priapism

26
Q

Long acting PDE inhibitors

A

Tadalafil-Cialis

27
Q

Adv effect impaired color discrimination

A

PDE 6 inhibitors

Pharmacology (1 decks)

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