AUBF EE Flashcards

1
Q

Why is the first-voided morning urine
specimen the most desirable specimen for
routine urinalysis?

A

D. Most concentrated specimen of the
day and therefore it is more likely that
abnormalities will be detected

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2
Q

The physical characteristic of color
is assessed when a routine urinalysis
is performed. What substance is
normally found in urine that is principally
responsible for its yellow coloration?

A

D. Urochrome

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3
Q

In certain malignant disorders, what
substance is found in the urine that turns
the urine dark brown or black on exposure
of the urine to air?

A

C. Melanin

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4
Q

What is the expected pH range of a freshly
voided urine specimen?

A

D. 4.5-8.0

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5
Q

Urine specimens should be analyzed as
soon as possible after collection. If urine
specimens are allowed to stand at room
temperature for an excessive amount of
time, the urine pH will become alkaline
because of bacterial decomposition of

A

B. Urea

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6
Q

Which term is defined as a urine volume
in excess of 2000 mL excreted over a
24-hour period?

A

C. Polyuria

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7
Q

The reagent test strips used for the
detection of protein in urine are most
reactive to

A

A. Albumin

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8
Q

A urine specimen that exhibits yellow
foam on being shaken should be suspected
of having an increased concentration of

A

C. Bilirubin

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9
Q

How should controls be run to ensure the
precision and accuracy of the reagent test
strips used for the chemical analysis of
urine?

A

C. Positive and negative controls should
be run on a daily basis.

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10
Q

The colorimetric reagent strip test for
protein is able to detect as little as 5-20 nig
of protein per deciliter. What may cause a
false-positive urine protein reading?

A

D. pH is greater than 8.0.

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11
Q

“Isosthenuria” is a term applied to a series
of urine specimens from the same patient
that exhibit a

A

D. Fixed specific gravity of approximately 1.010

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12
Q

A urine specimen is tested by a reagent
strip test and the sulfosalicylic acid test to
determine whether protein is present. The
former yields a negative protein, whereas
the latter results in a reading of 2+
protein. Which of the following statements
best explains this difference?

A

C. A protein other than albumin must be
present in the urine.

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13
Q

Which of the following is the major
organic substance found in urine?

A

D. Urea

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14
Q

Each of the following is included in the
quality assurance program for a urinalysis
laboratory. Which one represents a
preanalytical component of testing?

A

A. Setting collection guidelines for
24-hour urines

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15
Q

The presence of ketone bodies in urine
specimens may be detected by use of a
reagent strip impregnated with sodium
nitroprusside. This strip test is sensitive
to the presence of

A

B. Acetoacetic acid and acetone

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16
Q

A routine urinalysis is performed on a
young child suffering from diarrhea. The
reagent test strip is negative for glucose
but positive for ketones. These results may
be explained by which of the following
statements?

A

C. The child is suffering from increased
catabolism of fat because of decreased
intestinal absorption.

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17
Q

The principle of the colorimetric reagent
strip test for hemoglobin is based on the
peroxidase activity of hemoglobin in
catalyzing the oxidation of a dye with
peroxide to form a colored compound.
This method may yield false-positive
results for the presence of hemoglobin
when the urine specimen contains

A

C. Myoglobin

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18
Q

A reagent test strip impregnated with
a diazonium salt such as diazotized
2,4-dichloroaniline may be used to
determine which analyte?

A

D. Bilirubin

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19
Q

Which of the following will contribute to a
specimen’s specific gravity if it is present
in a person’s urine?

A

B. 85 mg/dL glucose

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20
Q

With infections of the urinary system,
white blood cells are frequently seen in
the urine sediment. What type of white
blood cell is seen the most frequently in
urine sediment?

A

D. Neutrophil

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21
Q

A random urine is collected from a patient
and the results obtained are as follows:
urine albumin =16 mg/dL and urine
creatinine = 140 mg/dL. These findings
are consistent with

A

A. Microalbuminuria

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22
Q

To detect more easily the presence of casts
in urine sediments, which microscopic
method can be used?

A

B. Phase-contrast microscopy

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23
Q

Which substance found in urinary
sediment is more easily distinguished
by use of polarized microscopy?

A

A. Lipids

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24
Q

“Glitter cell” is a term used to describe
a specific type of

A

D. Neutrophil

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25
Q

The final phase of degeneration that
granular casts undergo is represented
by which of the following casts?

A

D. Waxy

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26
Q

A 40-year-old female patient with a history
of kidney infection is seen by her physician
because she has felt lethargic for a few
weeks. She has decreased frequency of
urination and a bloated feeling. Physical
examination shows periorbital swelling
and general edema, including a swollen
abdomen. Significant urinalysis results
show the following: color = yellow;
appearance = cloudy/frothy; specific
gravity = 1.022;pH = 7.0; protein =
4+; 0-3 WBC/hpf; 0-1 RBC/hpf; 0-2
renal epithelial cells/hpf; 10-20 hyaline
casts/lpf; 0-1 granular casts/lpf; 0-1 fatty
casts/lpf; occasional oval fat bodies. Her
serum chemistries show significantly
decreased albumin, increased urea
nitrogen, and increased creatinine. These
findings suggest which condition?

A

C. Nephrotic syndrome

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27
Q

A 47-year-old female patient with
controlled type 2 diabetes mellitus
complains of urinary frequency and
burning. She provides a first-morning,
clean-catch specimen. Results show
color = yellow; appearance = cloudy;
pH = 6.5; a representative microscopic
high-power field is shown in Color
Plate 46B. Which of the following is true
for this patient?

A

B. The major formed elements are white
blood cells and yeast.

28
Q

Alkaptonuria, a rare hereditary disease, is
characterized by the urinary excretion of

A

D. Homogentisic acid

29
Q

A 22-year-old female clinical laboratory
student performs a urinalysis on her own
urine as part of a lab class. Significant
results include: color = yellow;
appearance = cloudy; pH = 7.5;
nitrite = positive; leukocyte
esterase - 2+; 25^0 WBC/hpf;
0-3 RBC/hpf; 2-5 squamous epithelial
cells/hpf; moderate bacteria. All other
chemistries and microscopic results
were normal. These findings suggest

A

C. Lower urinary tract infection

30
Q

Some clinical conditions are characterized
by unique urinalysis result patterns.
Which of the following shows such a
relationship?

A

B. Intensive dieting: increased ketones,
negative glucose

30
Q

Metastatic carcinoid tumors arising from
the enterochromaffin cells of the gastrointestinal tract are characterized by
increased excretion of urinary

A

D. 5-Hydroxyindole acetic acid

30
Q

Nitrite in a urine specimen suggests the
presence of

A

C. Bacteria

31
Q

If a fasting plasma glucose level of 100
mg/dL is obtained on an individual, what
is the expected fasting cerebrospinal fluid
(CSF) glucose level in mg/dL?

A

C. 65

31
Q

A 35-year-old man has just experienced
severe crush injuries sustained in a car
accident. He has a broken pelvis and right
femur and has numerous abrasions and
contusions. A random urinalysis specimen
shows a brown color and clear appearance.
pH is 6.0, protein is 1 + , and blood is 3+.
There is, however, only 0-1 RBC/hpf,
along with 0-3 WBC/hpf. Casts found
include hyaline (0-2/lpf) and granular
(0-1/Ipf). Other urine results are normal.
Which of the following is true about this
patient?

A

C. Rhabdomyolysis may be a cause for
the discrepant chemical/microscopic
blood findings.

32
Q

A 67-year-old male has routine testing
done and shows an estimated glomerular
filtration rate (eGFR) of 42 mL/min/1.73 m2.
Which of the following is true for this
patient?

A

D. The patient is in Stage 3 chronic
kidney damage.

32
Q

Which is true about the formed element
shown in Color Plate 47 *?

A

A. May be found in normal alkaline urine

32
Q

The major formed element in the highpower field shown in Color Plate 48 *
is most likely a

A

D. Fiber artifact

33
Q

Which of the following is true about the
final concentrating of urine in the kidney?

A

C. Vasopressin controls the collecting
duct reabsorption of water

34
Q

If a urine specimen is left standing at room
temperature for several hours, which of
the following changes may occur?

A

A. Multiplication of bacteria

35
Q

The formed element shown in Color
Plate 49B would usually be found in the
patient’s urine along with which soluble
biochemicals?

A

B. Ornithine and arginine

36
Q

A 13-year-old ice skater is having her
routine physical before the school year.
Her first morning urinalysis results
include color = straw; appearance =
hazy; pH = 6.0; protein = trace; a
representative microscopic high-power
field is shown in Color Plate 50B. All
other chemical results were normal. The
major formed elements are and
suggest .

A

D. Hyaline casts and mucus; normal
sediment

37
Q

Phenylketonuria may be characterized
by which of the following statements?

A

A. It may cause brain damage if
untreated.

38
Q

What condition is suggested by the
number of the formed element that
predominates in the high-power field
of Color Plate 5 !*?

A

D. Normal sample

38
Q

Which of the following will be characterized by an increased number of the urinary
component seen in Color Plate 52M?

A

A. Acute glomerulonephritis

39
Q

Xanthochromia of cerebrospinal fluid
(CSF) samples may be due to increased
levels of which of the following?

A

B. Protein

39
Q

With the development of fetal lung
maturity, which of the following phospholipid concentrations in amniotic fluid
significantly and consistently increases?

A

D. Phosphatidyl choline

39
Q

To determine amniotic fluid contamination
with maternal urine, which of the
following measurements could be used?

A

A. Creatinine concentration

40
Q

A patient has been diagnosed with an
upper gastrointestinal bleed. Which of the
following would be characteristic for this
condition?

A

C. Stool with a much darker brown/black
color

40
Q

A pleural effusion is found to have 3000
white blood cells per microliter and 5 g/dL
total protein. From this it can be determined that the patient’s effusion is

A

B. An exudate

40
Q
A
41
Q

The estimation of hyaluronic acid
concentration by measurement of
viscosity is useful in evaluating which
type of fluid?

A

D. Synovial

42
Q

Which of the following is characteristic of
an exudate effusion?

A

A. Leukocyte count >1000/uL

43
Q

Which of the following systems utilizes
polyelectrolytes to determine the specific
gravity of urine?

A

D. Reagent strip

44
Q

Which methods may be used to quantify
protein in both cerebrospinal fluid and
urine specimens?

A

D. Coomassie brilliant blue and
trichloroacetic acid

44
Q

Which of the following characteristics is
true of the primary urinary components
shown in Color Plate 53B?

A

A. Consist of uromodulin protein

45
Q

A characteristic of substances normally
found dissolved in the urine is that they
are all

A

A. Water soluble

45
Q

Which of the following statements applies
to the proper collection and handling of
CSF?

A

D. With low-volume specimens, a culture
is performed first, before cell counts
are done.

46
Q

Which of the following characteristics is
true for the urinary components shown in
Color Plate 54B?

A

B. Can also resemble cysteine crystals

46
Q

A patient sends the following question to
an online consumer health Web site: “I am
a 22-year-old female who experienced
increasing headaches, thirst, and decreasing energy. I was studying in the library
when I felt lightheaded and passed out.
I was taken to a hospital emergency
department and they told me that my
serum Acetest® was 40 mg/dL and urine
glucose was 500 mg/dL. What does this
mean?” How would you reply?

A

A. Your lab results pattern suggests
diabetes mellitus.

47
Q

Which urinalysis reagent strip test will
never be reported out as “negative”?

A

B. Urobilinogen

48
Q

Compared to the fecal occult blood test,
which of the following is a disadvantage
of performing a DNA-based test to detect
colon cancer?

A

C. The DNA test is more expensive.

48
Q

The following urinalysis results were
obtained on a 40-year-old white male
whose skin appeared yellowish during the
clinical examination. Color and clarity—
dark brown, clear; protein—negative;
glucose—negative; blood—negative;
ketones—negative; bilirubin— moderate;
urobilinogen—0.2 mg/dL. These results
are clinically significant in which of the
following conditions?

A

A. Bile duct obstruction

49
Q

Which of the following may be associated
with morphologic examination of
spermatozoa?

A

C. Papanicolaou stain may be used.

50
Q

Which condition is characterized by
increased levels of immunoglobulins in
the cerebrospinal fluid, originating from
within the central nervous system and not
from the general blood circulation?

A

D. Multiple sclerosis

51
Q

Which of the following statements
pertains to screening methods used to
determine pregnancy?

A

A. Immunoassays will use reagent
anti-hCG to react with patient hCG.

51
Q

The following urinalysis biochemical
results were obtained from a 4-month-old
infant who experienced vomiting and
diarrhea after milk ingestion and failed to
gain weight: pH—6; protein—negative;
glucose—negative; ketone—negative;
bilirubin—negative; Clinitest®—2+.
These results are clinically significant in
which of the following disorders?

A

D. Galactosemia

52
Q

Which of the following is a true statement?

A

C. Bacteria introduced into a urine
specimen at the time of the collection
will have no immediate effect on the
level of nitrite in the specimen.