au14_-_pharmacology_exam_3_20141210195121

Question 1

causes agranulocytosis

Answer 1

ticlopidine

Question 2

causes altered color vision

Answer 2

• qunidine- digoxin (yellow/green tinted)- sildenafil, vardenafil, tadalafil, avanafil, alprostadil (impaired blue/green color discrimination)

Question 3

causes altered eye conditions

Answer 3

• amiodarone (corneal deposits (optic neuritis)- sildenafil, vardenafil, tadalafil, avanafil, alprostadil (NAION)

Question 4

causes anorexia

Answer 4

quinidine

Question 5

causes anti-cholinergic/anti-vagal effects

Answer 5

• quinidine- disopyramide

Question 6

binds acidic drugs (like digoxin or oral anticoagulants)

Answer 6

cholestryamine, colestipol, coleselevam

Question 7

cannot be used with alpha1 blockers or nitrates

Answer 7

sildenafil, vardenafil, tadalafil, avanafil, alprostadil

Question 8

coronary vasodilator

Answer 8

adenosine

Question 9

causes deposits in skin (blue/gray)

Answer 9

amiodarone

Question 10

causes diabetes

Answer 10

niacin

Question 11

enhanced by hypokalemia

Answer 11

digoxin

Question 12

causes fatal pulmonary fibrosis

Answer 12

amiodarone

Question 13

decreases absorption of fat-soluble vitamins

Answer 13

cholestryamine, colestipol, coleselevam

Question 14

first pass effect

Answer 14

• lidocaine- glyceryl trinitrate (nitroglycerin)

Question 15

causes hemorrhage

Answer 15

• warfarin- dabigatran

Question 16

causes hypotension

Answer 16

• beta blockers (“olol’s”)- glyceryl trinitrate (nitroglycerin)

Question 17

causes itching

Answer 17

niacin

Question 18

causes loose stools/leakage

Answer 18

• orlistat- olestra

Question 19

causes lupus-like syndrome in slow acetylators

Answer 19

procainamide

Question 20

metabolized by P450

Answer 20

• sildenafil, vardenafil, tadalafil, avanafil, alprostadil- warfarin- dabigatran- lovastatin, simvastatin, atorvastatin, fluvastatin, pravastatin, rosuvastatin, pitavastatin

Question 21

causes myocardial infarction

Answer 21

• sildenafil, vardenafil, tadalafil, avanafil, alprostadil - epoietin alfa, darbepoietin, peginesatide

Question 22

causes myositis (at worst, rhabdomyolysis)

Answer 22

lovastatin, simvastatin, atorvastatin, fluvastatin, pravastatin, rosuvastatin, pitavastatin

Question 23

causes neutropenia

Answer 23

ticlopidine

Question 24

causes osteoporosis

Answer 24

heparin

Question 25

has an effect on pregnancy

Answer 25

- fondaparinux- warfarin (category X)- hydroxyurea (category D)- lovastatin, simvastatin, atorvastatin, fluvastatin, pravastatin, rosuvastatin, pitavastatin (category X)- folic acid deficiency (neural tube defect)

Question 26

prodrug

Answer 26

- dabigatran- lovastatin, simvastatin, atorvastatin, fluvastatin, pravastatin, rosuvastatin, pitavastatin

Question 27

causes skin flushing

Answer 27

- glyceryl trinitrate (nitroglycerin)- niacin

Question 28

given via injection/subcutaneously

Answer 28

- heparin (too large)- fondaparinux- hirudin- vitamin B12 (for pernicious anemia)

Question 29

given sublingually

Answer 29

glyceryl trinitrate (nitroglycerin)

Question 30

given via IV

Answer 30

- lidocaine (first pass)- adenosine- abciximab- tirofiban, eptifibatide- streptokinase, urokinase, tissue plasminogen activator

Question 31

causes spinal hematoma

Answer 31

enoxaparin, dalteparin

Question 32

causes thrombocytopenia

Answer 32

- heparin (heparin-induced thrombocytopenia)- abciximab- tirofiban, eptifibatide

Question 33

causes uric acid and gout

Answer 33

niacin

Question 34

causes liver damage

Answer 34

- amiodarone- lovastatin, simvastatin, atorvastatin, fluvastatin, pravastatin, rosuvastatin, pitavastatin- lomitapide

Question 35

used for atrial tachycardia

Answer 35

adenosine

Question 36

drug of choice for cardiac arrests

Answer 36

amiodarone

Question 37

used for digoxin poisoning

Answer 37

anti-digoxin antibodies

Question 38

used for heparin overdose

Answer 38

protamine sulfate

Question 39

used if patient has heparin-induced thrombocytopenia

Answer 39

hirudin

Question 40

used for acute iron overdose

Answer 40

chelating agent (deferoxamine)

Question 41

used for chronic iron overdose (hemachromatosis)

Answer 41

phlebotomy (bleeding)

Question 42

used for pernicious anemia

Answer 42

vitamin B12 injected

Question 43

used for plastic surgery

Answer 43

bivalirudin, desirudin, argatroban

Question 44

used for pulmonary hypertension

Answer 44

sildenafil, vardenafil, tadalafil, avanafil, alprostadil

Question 45

used post-surgery for spinal tap or spinal surgery

Answer 45

rivaroxaban, apixaban

Question 46

used for ventricular tachycardia

Answer 46

lidocaine, mexiletine