Atypical Mycobacteria Flashcards

1
Q

Why are the atypical mycobacteria atypical?

A

They are environmentally acquired infections that cause neither Tb nor leprosy

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2
Q

How does atypical mycobacterial infection manifest in an immunocompetent adult?

A

Cutaneous infection

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3
Q

How does atypical mycobacterial infection manifest in kids?

A

Scrofula

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4
Q

Immunosuppressed hosts can have systemic symptoms from atypical mycobacterial infection- what two bugs are most likely to cause this?

A

M. kansasii or MAI/MAC

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5
Q

Is it easy to treat atypical mycobacterial infections?

A

No!

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6
Q

Are antibiotics required to treat atypical mycobacterial infections?

A

May require multiple antibiotics

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7
Q

Can M. leprae be cultured?

A

No

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8
Q

What is the slowest growing human pathogen?

A

M. leprae

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9
Q

What temperature does M. leprae prefer?

A

30 C

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10
Q

Describe the incubation period of M. leprae

A

It’s very long

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11
Q

Does M. leprae transmit easily?

A

No

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12
Q

Are most humans susceptible to disease by M. leprae?

A

No- only 5-10%

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13
Q

What are the two classifications of Leprosy (Hansen’s Disease)?

A

Tuberculoid to Lepromatous

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14
Q

Describe tuberculoid leprosy

A

Strong CMI response contains infection and damages nerves. Few Bacilli are seen. Positive PPD

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15
Q

Describe lepromatous leprosy

A

Weak CMI response. Many bacilli are seen. Extensive cutaneous symptoms. Negative PPD.

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16
Q

How do you diagnose tuberculoid leprosy?

A

Sensitivity of biopsy and serology is low- use history, physical, and PPD

17
Q

How do you diagnose lepromatous leprosy?

A

Easily diagnosed by skin smear, biopsy, molecular probe, and serology

18
Q

What’s unique about lepromin PPD tests?

A

They test immunocompetence, not exposure! Positive test–> Strong CMI–>Tuberculoid

19
Q

How do you treat leprosy?

A

Dapsone + rifampin for 2 years

20
Q

When do you add thalidomide to the treatment plan?

A

When lepromatous leprosy patients develop erythema nodosum leprosum