Atypical Antidepressant

Question 1

Give examples of atypical antidepressants

Answer 1

mirtazapine, bupropion

Question 2

What is the mode of action of mirtazapine?

Answer 2

enhances serotonin and norepinephrine neurotransmission by acting as an antagonist at presynaptic alpha2 receptors. There may be antagonism at the 5-HT2 receptors as well

Question 3

What are the side effects of mirtazapine?

Answer 3

Sedating because of its potent antihistaminic activity (beneficial for patients with insomnia)
Increased appetite
Weight gain

Question 4

What are the benefits of mirtazapine other than its antidepressant effects?

Answer 4

Does not cause sexual dysfunction or have antimuscarinic side effects. It can block serotonergic side effects (serotonin syndrome) if used with SSRI’s

Question 5

What is the mode of action of bupropion?

Answer 5

Weak dopamine and norepinephrine reuptake inhibitor use to alleviate symptoms of depression.

Question 6

What are the other useful properties of bupropion

Answer 6

Decrease cravings and decrease withdrawal symptoms of nicotine in patients trying to quit smoking

Question 7

What are the side effects if bupropion?

Answer 7

Dry mouth, sweating, nervousness, tremor and dose dependent increased risk for seizures

Question 8

When is the use of bupropion inappropriate?

Answer 8

In patients with eating disorders or at risk for seizures

Question 9

What are the benefits of using bupropion?

Answer 9

minimal risk of sexual dysfunction