Atrial Septal Defects Flashcards
ASDs: General Info
- Communication between LA and RA
- Accounts for 10% of all CHDs
- Shunt usually L-R (LAP > RAP)
- Dilatation of high heart (increased volume of blood to right side of heart)
Emybyological contribution of which structures form the IAS?
- Primum atrial septum
- Secundum atrial septum
- Endocardial cushions
Contribution of premium atrial septum in forming IAS?
- First atrial septum to form
- Arises from roof of the atrium and grows inferiorly towards the endocardial cushions
Contribution of secundum atrial septum in forming IAS?
- Grows from roof of atria and overlaps with primum septum
- Doesn’t grow far enough to lose opening = forming foramen ovale
Contribution of endocardial cushions in forming IAS?
- Before primum fuses with cushions, septum is performed in upper part forming foramen secundum
What is the importance of the foramen ovale in foetal circulation?
- Remains open until birth to allow oxygenated blood to be shunted to rest of the body
- Allows blood supply to the LA
Overview of foetal circulation?
- Oxygenated blood from maternal placenta travels to foetal heart via the IVC
- Within RA, majority of oxygenated blood shunted across foramen ovale with help of Eustachian valve
- Oxygenated blood in RA travels to LV and aorta, and to foetal brain
Modifications of Sinus Horns throughout development?
- Progressive enlargement of right sinus horn develops into SVC and IVC
- Regression of left sinus horn contributes to formation of coronary sinus
What are the types of ASDs from most to least common?
- Osmium secundum ASD (80% of all ASDs)
- Ostrium primum ASD (15% of all ASDs)
- Sinus Venosus (SV) ASD
a. Superior SV ASD 5-10%
b. Inferior SV ASD 2% - Coronary Sinus (CS) ASD (<1%)
Secundum ASD location?
- Fossa ovalis
- Seen towards top of atria
- Difficult to identify when IAS orientated parallel to u/s beam due to drop out of septum
Cause of secundum ASD?
- Excessive cell death or inadequate development
- Reabsorption of septum premium
- Or inadequate development of septum secundum
Location of primum ASD?
- Inferior portion of atrial septum near primitive foramen primum
- Inferior atrial septum near the cardiac crux
Cause of primum ASD?
- Failure of primum septum to fuse with the endocardial cushion
- Or deficiency of endocardial cushion tissue
What are the two types of sinus venosus ASD?
- Superior SV ASD
- Inferior SV ASD
How to sinus venosus ASDs occur?
Defects result from maldevelopment of the sinus venosus and sinus horns