Atopic Dermatitis

Question 1

Refers to a predisposition to excessive IgE response

Answer 1

Atopic

Question 2

Chronic relapsing skin disease is common in what age groups?

Answer 2

infancy and childhood

Question 3

How many percent of children does AD affect worldwide?

Answer 3

10-20%

Question 4

How many percent of children does AD occur in the first 6 months of life? first year of life? Before age 5?

Answer 4

45%, 60%, 85%

Question 5

highly differentiated flattended keratinocytes

Answer 5

Corneocytes

Question 6

derived from pro-fillagrin and helps maintain skin hydration

Answer 6

NMF

Question 7

Encases the corneocytes preventing water loss

Answer 7

lipid lamellae

Question 8

hold corneocytes together and maintain the integrity of the barrier

Answer 8

corneodesmosomes

Question 9

example of a protease in the skin barrier

Answer 9

KLK7

Question 10

example of a protease inhibitor in the skin barrier

Answer 10

cystatin A and LEKTI

Question 11

Characteristics of the acute phase

Answer 11

intensely pruritic, erythematous, infiltration by Th2 cells

Question 12

Characteristics of the chronic phase

Answer 12

Th1 type of response, rise in IL-12

Question 13

Major criteria for the Hanifin-Rajka criteria

Answer 13

1. Pruritus
2. typical morphology and distribution
3. chronically relapsing dermatitis
4. family history

Question 14

Minor criteria of the Hanifin-Rajka criteria

Answer 14

1. Anterior neck folds
2. chelitis
3. influenced by env’t and emotions
4. Dennie-Morgan infraorbital folds
5. Early age of onset
6. Ichthyosis, palmar hyperlinearity, keratosis pilaris
7. immediate skin test reactivity
8. orbital darkening
9. pityriasis alba
10. elevated serum IgE
11. tendency towards recurrent cutaneous infections
12. xerosis

Question 15

What stage of AD is being described? pruritic, erythematous papules, patches, vesicles; weeping and exudative; seen on extensor surfaces

Answer 15

Infant stage

Question 16

What stage of AD is being described? large lichenified plaques and scaling, affliction of flexural folds

Answer 16

Adult stage

Question 17

What stage of AD is being described? less weeping and exudative, more lichenified and excoriated, flexor surfaces affected; staph infection

Answer 17

Childhood stage

Question 18

Flaking of skin early in life due to increase in penetration of anythign applied to the skin

Answer 18

Netherton syndrome

Question 19

malignancy with dermatitis, presents with punched out lesions on x-ray

Answer 19

Letterer-Siwe disease or Langerhans histiocytosis

Question 20

lesions on face and diaper area (acrodermatitis), chronic diarrhea and failure to thrive

Answer 20

Zinc deficiency

Question 21

Wiskott-Aldrich syndrome Triad

Answer 21

Thrombocytopenia, Recurrent infection, Eczema

Question 22

Top 8 Food Allergens

Answer 22

Milk
Egg
Peanut
Nuts
Wheat
Fish
Shellfish
Soy

Question 23

Microbial agents that aggravate AD

Answer 23

S. aureus, Malassezia

Question 24

natural antimicrobial found in the skin but congenitally defective in people with AD

Answer 24

Canthelecidins

Question 25

the gold standard in treatment of AD

Answer 25

topical steroids

Question 26

topical non-steroidal agent for AD

Answer 26

tacrolimus