Atenolol (Tenormin) Flashcards

1
Q

Where is atenolol absorbed?

A

50% absorbed from the GI tract

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2
Q

Does it readily cross the blood-brain barrier?

A

No

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3
Q

Where is it eliminated?

A

Urine and feces

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4
Q

What kind of beta adrenergic blocker is it?

A

A beta1-adrenergic blocker

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5
Q

What is the trade name?

A

Tenormin

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6
Q

What does it treat?

A

To treat hypertension, angina pectoris, myocardial infarction, and heart failure

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7
Q

Which beta receptor does it block and when stimulated what happens?

A

Blocks beta1-adrenergic receptors, decreases blood flow to the periphery, suppresses renin-release

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8
Q

What are the side effects?

A

Drowsiness, dizziness, fainting, depression, weakness, nausea, vomiting, diarrhea, cool extremities, leg pain, impotence, decreased libido

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9
Q

What are the contraindications?

A

Sinus bradycardia, heart block > first degree, cardiogenic shock, pulmonary edema, acute bronchospasm, uncompensated cardiac failure, pregancy, lactation, renal dysfunction, diabetes mellitus

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10
Q

What are the adverse reactions?

A

Bradycardia, hypotension, heart failure, masking of hypoglycemia, bronchospasm, pulmonary edema, dysrhythmias

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11
Q

When is the onset if taken PO?

A

1 hour

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12
Q

When is the peak if taken PO?

A

2 to 4 hours

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13
Q

How long is the duration if taken PO?

A

24 hours

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14
Q

When is the onset if administered intravenously?

A

Immediately

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15
Q

When is the peak if administered intravenously?

A

5 mins

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16
Q

How long is the duration if administered intravenously?

A

24 hours

17
Q

What increases the drugs action?

A

If taken with atropine and other anticholinergics

18
Q

What decreases the effect of the drug?

A

If taken with NSAIDs

19
Q

What induces risk of hypoglycemia?

A

If taken with insulin and sulfonylureas

20
Q

What increases the likelihood of increased hypertension?

A

If taken with Prazosin and Terazosin