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Cancer MT & AT > AT L2 Platinums - the drugs > Flashcards

AT L2 Platinums - the drugs Flashcards

1
Q

Developments in the 70s

A

Pts treated with cisplatin

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2
Q

Developments in the 80s

A

Oxalyplatin - broader spec

Carboplatin - improved safety

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3
Q

Developments in the 90s

A

Statraplatin - oral admin

Picoplatin - broad spec and retention against acquired cisplatin resistance

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4
Q

Developments in the 00s

A

Aroplatin - liposomal preparation

Prolindac - platinum linked to water soluble polymer to use the EPR effect (retention of macromolecules in tumours)

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5
Q

What is DACH

A

diaminocyclohexane as contained in oxaliplatin and aroplatin gives increase resistance to cells producing increased glutathione.

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Cancer MT & AT (11 decks)

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