AT 101 Module 2 Flashcards
Explain general safety as it pertains to the use of essential oils.
Most essential oils represent little or no risk if used correctly in aromatherapy, however just as other natural products may be toxic (i.e. hemlock) and some essential oils that are considered to be hazardous.
When using essential oils, we must take into consideration the dosage, frequency of use and application of a particular essential oil to determine if it poses a threat
In general, toxicity is dose dependent. The greater the amount of essential oil applied, the greater the risk of toxicity. The degree of toxicity depends on the route of application, and oral administration carries the highest risk.
The main reason an essential oil will pose a toxicity risk is oral overdosing, however similar results may be expected if the same amount of essential oil enters the body topically
Understanding the chemistry of an essential oil is a very useful basis for understanding essential oil toxicity. The chemistry of essential oils is complex and many of the compounds that make up the oils are hard to detect (trace elements).
Define the term irritation as it pertains to essential oils.
Irritation is a difficult condition to define. Some essential oils classified as potential skin irritants may not provoke a reaction in everyone. Conversely, a person may have an idiosyncratic reaction to an essential oil that is considered safe for the skin.
It is recommended that a person with sensitive skin do a patch test on a small area of skin before using the essential oil(s). This can be done by applying the essential oils) at double the concentration they would normally be used to the inside of the forearm (place drops on a bandage and then apply bandage to the skin). Leave for 24 - 48 hours. If there was irritation, it will present as redness, itchiness, swelling or blistering.
Essential oils with high proportions of either aldehydes or phenols are often the culprits in provoking irritation.
Define the term sensitization as it pertains to essential oils.
Sensitization (allergic skin reaction)
A skin allergy is a systemic reaction and autoimmune response which usually manifests as a rash. A Japanese study showed that the skin of men tends to be more than twice as sensitive as that of women. This study also showed that in situations of severe stress, lack of sleep etc. all skin types become more sensitive. Once a person has experienced sensitization to a particular essential oil, they will likely always have an adverse reaction to that essential oil.
Dermatitis is usually an indication that a person’s skin is sensitive and so avoidance of the essential oils that typically cause irritation should be avoided or used with extreme caution.
What is usually a good indication that a person’s skin is sensitive.
Dermatitis
Define the term toxicity as it pertains to essential oils.
- Acute toxicity refers to poisoning by way of ingesting or the absorption of too much essential oil at one time.
- Chronic toxicity occurs when a small amount of a potentially toxic essential oil is repeatedly applied over a period of time and is thus damaging the body in some way or when any essential oil is used in excess over a period of time. Toxicity can also occur if a person has either liver or kidney impairment or disease.
Toxicology also includes the study of hazards related to pregnancy and cancer, skin allergy and/or phototoxicity, liver and kidney dysfunction, effects on the CNS and the endocrine system and damage to the eyes.
Although some people may experience idiosyncratic reactions to particular essential oils, in general toxicity is dose dependant. However, there are some instances where even low amounts can produce severe reactions such as allergies and phototoxicity.
The degree of toxicity also depends on the mode of application and oral ingestion carries the highest risk — especially if the essential oil is taken undiluted.
Define the term quenching as it relates to essential oils (hint: there are two ways quenching can occur). Give a couple of examples.
- Individual components in essential oils are known to have certain toxic effects and yet in the whole oil these effects are often quenched by one of the other components contained in the oil. For example, citral on its own is a skin irritant while the whole essential oil of lemon, which contains citral, is not due to the presence of (+)-limonene and its synergistic quenching effects. So, whole or complete essential oils are usually more effective than an individual isolate and have fewer side effects.
- If an essential oil contains one or more components which are thought to be hazardous in some way, the unwanted action can be “quenched” by adding a nullifying component in a different essential oil. For example, if you were to combine the essential oils of grapefruit or sweet orange with lemongrass in a 50/50 dilution, the citral in the lemongrass will be quenched or nullified the by the limonene in the grapefruit or sweet orange.
What is oxidation? What three things are responsible for oxidation?
Oxidation is the addition of oxygen (or removal of electrons or hydrogen) from an organic molecule. oxygen, heat and light.
The effect of oxygen on essential oils is called oxidation and tends to occur in essential oils rich in monoterpene hydrocarbons, such as citrus and pine oils. Oxidation is accelerated by heat and light. Oxidation changes the chemical composition of an essential oil which in turn alters the therapeutic value and can make an essential oil that is usually safe to use hazardous.
Describe the term Contamination
Contamination of an essential oil may be by way of pesticides or herbicides. These are used in large scale essential oil crop cultivation to control pests, parasites, diseases and weeds and to raise harvest yields. Steam distillation, solvent extraction and expression do not eliminate biocides contained in pesticides and herbicides. This makes a great argument for using only organic essential oils!
Describe the term Adulteration
Adulteration refers to the fact that a substance has been added to modify the composition of an essential oil. Typically, the substance will be a synthetic aroma chemical or an aroma chemical extracted from a less expensive essential oil. A common example of this is geranium oil —Pelargonium graveolens.
Describe the term Degradation
Degradation of essential oils is a process by which the quality of the essential oil is reduced over time. This usually occurs with essential oils because of prolonged storage or poor storage conditions. The main factors responsible for degradation are oxygen, heat and light. The effect of oxygen on essential oils is called oxidation and tends to occur in essential oils rich in monoterpene hydrocarbons, such as citrus and pine oils. Oxidation is accelerated by heat and light.
Explain the general toxicological risks for the Liver
The liver contains a substance called reduced glutathione, which mops up reactive molecules i.e. free radicals, before they can damage DNA or protein. However, the liver contains only a limited amount of glutathione and if this is depleted (temporarily), reactive molecules are able to attack and seriously damage the liver and blood cells, before the glutathione is replaced. If the damage is serious enough, it can result in liver failure or haemolytic anaemia and possible death.
It is unlikely that any essential oil could be absorbed in a large enough quantity to deplete glutathione through dermal application, however essential oils administered orally could probably do so.
Explain the general toxicological risks for the Kidneys
Most drugs are excreted through the kidneys. Many water soluble molecules are secreted into the kidney tubules and reach the urine. The more water soluble essential oil constituents, such as terpenoid alcohols, aldehydes and esters are probably removed in this way
Because kidneys receive the peak plasma concentrations of all substances present in the blood, kidney tubule cells are exposed to higher levels of chemicals than are other body cells. Consequently, the kidney is extremely vulnerable to damage caused by foreign molecules, whether they are from drugs or essential oil constituents. However, there is no evidence to suggest that essential oils can damage healthy kidneys at the doses that are given in aromatherapy.
A diseased kidney is usually less able to handle large quantities of essential oils and so caution should be used when essential oils are given orally to people with kidney disease. In kidney disease, the bloods’ ability to coagulate is reduced and so anti-coagulant essential oils could exacerbate the condition potentially resulting in internal haemorrhage. It is recommended that such oils not be given ~orally in kidney disease or if the person is on blood thinners i.e. Warfarin.
Explain the general toxicological risks for the Central Nervous System.
The CNS is particularly sensitive to chemicals and toxicological agents of all types. Because of this it is possible that some essential oil constituents, when given in high doses might have CNS toxicity. Many essential oils, being fat soluble, can probably gain rapid entry into the CNS through the blood-brain barrier.
Explain the general toxicological risks for the Endocrine System
Together with the nervous system, the endocrine system constitutes the internal communication mechanism of the body. This is done by a group of ductless glands whose function is to synthesize and store chemicals called hormones and then to release them into the blood supply. Once in the bloodstream, hormones are recognized by their specific target tissues, which then respond accordingly. Some essential oils are listed as having estrogen-like properties however this is considered to be significant only when the essential oils are ingested orally.
Explain the general toxicological risks for the Endocrine System
Together with the nervous system, the endocrine system constitutes the internal communication mechanism of the body. This is done by a group of ductless glands whose function is to synthesize and store chemicals called hormones and then to release them into the blood supply. Once in the bloodstream, hormones are recognized by their specific target tissues, which then respond accordingly. Some essential oils are listed as having estrogen-like properties however this is considered to be significant only when the essential oils are ingested orally.
Explain the general toxicological risks for the Reproductive System and Reproduction
Studying the effects of essential oils during pregnancy is very difficult. Most tests for drugs and other foreign materials during pregnancy are conducted on animals and correlate very poorly with the human situation It is estimated that substances with a molecular weight of less than 1000 amu can cross the placenta and since all essential oil constituents have molecular weights below 500 it can be assumed that they are all capable of crossing the placenta. The blood-brain barrier is underdeveloped at and before birth which makes it likely that the compounds which do cross the placenta will reach the fetal central nervous system. This does not necessarily mean that there is a risk of toxicity to the fetus, however in my opinion, care should be taken with specific, potentially harmful essential oils